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Back to Cardiology Drug index
Brand Name: Altace
Name: Ramipril
Pregnancy Category C
Drug classes
Mechanism of action of Altace
Altace blocks ACE from converting angiotensin I to angiotensin II, a
powerful vasoconstrictor, leading to decreased blood pressure,
decreased
aldosterone secretion, a small increase in serum potassium levels, and
sodium and fluid loss; increased prostaglandin synthesis also may be
involved in the antihypertensive action.
Indications of Altace
Contraindications/cautions of Altace
- The presence of allergy to Altace
- pregnancy
(embryocidal in preclinical studies)
Use caution in the presence of
Adverse effects
of Altace
- GI: Gastric irritation, aphthous ulcers,
peptic ulcers,
cholestatic jaundice,
hepatocellular injury, anorexia,
constipation
- CV:
Tachycardia,
angina pectoris,
myocardial infarction,
Raynaud's
syndrome,
Congestive heart failure, hypotension in salt/volume depleted patients
- Hematologic: Neutropenia, agranulocytosis, thrombocytopenia,
hemolytic
anemia, fatal pancytopenia
-
GU: Proteinuria, renal insufficiency,
renal failure, polyuria,
oliguria,
urinary frequency
- Dermatologic: Rash,
pruritus, pemphigoid-like reaction, scalded mouth
sensation, exfoliative dermatitis, photosensitivity,
alopecia
-
Other:
Cough, malaise, dry mouth,
lymphadenopathy
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