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Brand Name: Altace
Pregnancy Category C
Mechanism of action of Altace
Altace blocks ACE from converting angiotensin I to angiotensin II, a
powerful vasoconstrictor, leading to decreased blood pressure,
aldosterone secretion, a small increase in serum potassium levels, and
sodium and fluid loss; increased prostaglandin synthesis also may be
involved in the antihypertensive action.
Indications of Altace
Contraindications/cautions of Altace
- The presence of allergy to Altace
(embryocidal in preclinical studies)
Use caution in the presence of
- GI: Gastric irritation, aphthous ulcers,
hepatocellular injury, anorexia,
Congestive heart failure, hypotension in salt/volume depleted patients
- Hematologic: Neutropenia, agranulocytosis, thrombocytopenia,
anemia, fatal pancytopenia
GU: Proteinuria, renal insufficiency,
renal failure, polyuria,
- Dermatologic: Rash,
pruritus, pemphigoid-like reaction, scalded mouth
sensation, exfoliative dermatitis, photosensitivity,
Cough, malaise, dry mouth,
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