Brand Name: Altace
Pregnancy Category C
- Angiotensin-converting enzyme (ACE) inhibitor
Mechanism of action of Altace
Altace blocks ACE from converting angiotensin I to angiotensin II, a powerful vasoconstrictor, leading to decreased blood pressure, decreased aldosterone secretion, a small increase in serum potassium levels, and sodium and fluid loss; increased prostaglandin synthesis also may be involved in the antihypertensive action.
Indications of Altace
- Treatment of hypertension alone or in combination with thiazide-type diuretics
Contraindications/cautions of Altace
- The presence of allergy to Altace
- pregnancy (embryocidal in preclinical studies)
Use caution in the presence of
- impaired renal function
- Congestive heart failure
- salt/volume depletion
Adverse effects of Altace
- GI: Gastric irritation, aphthous ulcers, peptic ulcers, cholestatic jaundice, hepatocellular injury, anorexia, constipation
- CV: Tachycardia, angina pectoris, myocardial infarction, Raynaud's syndrome, Congestive heart failure, hypotension in salt/volume depleted patients
- Hematologic: Neutropenia, agranulocytosis, thrombocytopenia, hemolytic anemia, fatal pancytopenia
- Dermatologic: Rash, pruritus, pemphigoid-like reaction, scalded mouth sensation, exfoliative dermatitis, photosensitivity, alopecia
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