Powered by


                    Home  |  Forums  |  Humor  |  Advertising  |  Contact
   Health Questions

   News via RSS






   Forum Archives





















   Primary Care






   Other Sections


   Research Tools

   Medical Tutorials

   Medical Software




Back to Cardiology Drug index

Back to Angiotensin-converting enzyme (ACE) inhibitors

Name: Captopril

Pregnancy Category C

Drug classes

Mechanism of action

Blocks ACE from converting angiotensin I to angiotensin II, a powerful vasoconstrictor, leading to decreased blood pressure, decreased aldosterone secretion, a small increase in serum otassium levels, and sodium and fluid loss; increased prostaglandin synthesis also may be involved in the antihypertensive action.


  • Treatment of hypertension alone or in combination with thiazide-type diuretics
  • Treatment of CHF in patients who do not respond adquately to conventional therapy; used with diuretics anddigitalis

Unlabeled uses: management of hypertensive crises; treatment of rheumatoid arthritis; diabetic nephropathy, diagnosis of anatomic renal artery stenosis, hypertension related to scleroderma renal crisis; diagnosis of primary aldosteronism, idiopathic edema; Bartter's syndrome; Raynaud's syndrome; hypertension of Takayasu's disease


  • Allergy to captopril; impaired renal function; CHF; salt/volume depletion, lactation.

Adverse effects

  • CV: Tachycardia, angina pectoris, myocardial infarction, Raynaud's syndrome, CHF, hypotension in salt/volume depleted patients
  • GI: Gastric irritation, aphthous ulcers, peptic ulcers, dysgeusia, cholestatic jaundice, hepatocellular injury, anorexia, constipation
  • Hematologic: Neutropenia, agranulocytosis, thrombocytopenia, hemolytic anemia, fatal pancytopenia
  • GU: Proteinuria, renal insufficiency, renal failure, polyuria, oliguria, urinary frequency
  • Dermatologic: Rash, pruritus, pemphigoid-like reaction, scalded mouth sensation, exfoliative dermatitis, photosensitivity, alopecia
  • Other: Cough, malaise, dry mouth, lymphadenopathy
advertisement.gif (61x7 -- 0 bytes)

Are you a doctor or a nurse?

Do you want to join the Doctors Lounge online medical community?

Participate in editorial activities (publish, peer review, edit) and give a helping hand to the largest online community of patients.

Click on the link below to see the requirements:

Doctors Lounge Membership Application


 advertisement.gif (61x7 -- 0 bytes)