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Back to Cardiology Drug index

Back to Alpha Blockers

Doxazosin mesylate - Cardura

Pregnancy Category B

Drug classes
Alpha adrenergic-blocking agent

Mechanism of action
Selectively blocks postsynaptic alpha1-adrenergic receptors, leading to vasodilatation without reflex tachycardia, it does not block alpha2 presynaptic receptors. Increases HDL and the HDL to cholesterol ratio, while lowering total cholesterol and LDL, making it desirable for patients with atherosclerosis or hyperlipidemia.

Treatment of mild to moderate hypertension


Use caution in the presence of allergy to doxazosin, CHF, renal failure, hepatic impairment.

Adverse effects
Initial syncopal attack (First Dose Phenomenon)
Alpha blocking effects: nasal congestion, failure of ejaculation, postural hypotension
Sodium and water retention leading to edema (add a diuretic).

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