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Doxazosin mesylate - Cardura
Pregnancy Category B
Alpha adrenergic-blocking agent
Mechanism of action
Selectively blocks postsynaptic alpha1-adrenergic receptors, leading to
vasodilatation without reflex tachycardia, it does not block alpha2 presynaptic
receptors. Increases HDL and the HDL to cholesterol ratio, while lowering
total cholesterol and LDL, making it desirable for patients with atherosclerosis
Treatment of mild to moderate hypertension
Use caution in the presence of allergy to doxazosin, CHF, renal failure,
Initial syncopal attack (First Dose Phenomenon)
Alpha blocking effects: nasal congestion, failure of ejaculation, postural
Sodium and water retention leading to edema (add a diuretic).
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