| |
Back to Cardiology Drug index
Doxazosin mesylate - Cardura
Pregnancy Category B
Drug classes
Alpha adrenergic-blocking agent
Antihypertensive
Mechanism of action
Selectively blocks postsynaptic alpha1-adrenergic receptors, leading to
vasodilatation without reflex tachycardia, it does not block alpha2 presynaptic
receptors. Increases HDL and the HDL to cholesterol ratio, while lowering
total cholesterol and LDL, making it desirable for patients with atherosclerosis
or hyperlipidemia.
Indications
Treatment of mild to moderate hypertension
Contraindications
Lactation.
Use caution in the presence of allergy to doxazosin, CHF, renal failure,
hepatic impairment.
Adverse effects
Initial syncopal attack (First Dose Phenomenon)
Alpha blocking effects: nasal congestion, failure of ejaculation, postural
hypotension
Sodium and water retention leading to edema (add a diuretic).
|
|
|
|
Are you a doctor or a nurse?
Do you want to join the Doctors Lounge online medical community?
Participate in editorial activities (publish, peer review, edit) and
give a helping hand to the largest online community of patients.
Click on the link below to see the requirements:
Doctors Lounge Membership
Application |
|
|
|
send
to a friend
printer
friendly version
