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Terazosin hydrochloride - Hytrin

Drug classes
Antihypertensive drug
Alpha-adrenergic blocking drug

Mechanism of action
Selectively blocks postsynaptic alpha1-adrenergic receptors, leading to vasodilatation without reflex tachycardia, it does not block alpha2 presynaptic receptors.

Indications
Treatment of hypertension
Treatment of symptomatic benign prostatic hyperplasia (BPH)

Contraindications
Contraindicated in the presence of hypersensitivity to terazosin, lactation.

Use caution in the presence of CHF, renal failure, pregnancy.

Adverse effects
CNS: Dizziness, headache, drowsiness, lack of energy, weakness, somnolence, nervousness, vertigo, depression, paresthesia
GI: Nausea, vomiting, diarrhea, constipation, abdominal discomfort or pain
CV: Palpitations, sodium and water retention, increased plasma volume, edema, syncope, tachycardia, orthostatic hypotension, angina
Respiratory: Dyspnea, nasal congestion, sinusitis
GU: Urinary frequency, incontinence, impotence, priapism
EENT: Blurred vision, reddened sclera, epistaxis, tinnitus, dry mouth, nasal congestion
Dermatologic: Rash, pruritus, alopecia, lichen planus
Other: Diaphoresis, lupus erythematosus

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