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Name: Gemfibrozil
Pregnancy Category B
Drug classes
Therapeutic actions
Inhibits peripheral lipolysis and decreases the hepatic excretion of
free fatty acids; this reduces hepatic triglyceride production; inhibits
synthesis of VLDL carrier apolipoprotein; decreases VLDL production; increases
HDL concentration.
Indications
Hypertriglyceridemia in adult patients with triglyceride levels 750 mg/dl
(type IVand V hyperlipidemia) at risk of abdominal pain and pancreatitis
who do not respond to diet therapy
Reduction of coronary heart disease risk, possibly effective
Contraindications/cautions
Allergy to gemfibrozil, hepatic or renal dysfunction, primary biliary
cirrhosis, gallbladder disease, pregnancy, lactation.
Adverse effects
- CNS: Headache, dizziness, blurred vision, vertigo, insomnia, paresthesia,
tinnitus, fatigue, malaise, syncope
- GI: Abdominal pain, epigastric pain, diarrhea, nausea, vomiting, flatulence,
dry mouth, constipation, anorexia, dyspepsia, cholelithiasis
- Hematologic: Anemia, eosinophilia, leukopenia, hypokalemia, liver
function changes, hyperglycemia
- GU: Impairment of fertility
- Dermatologic: Eczema, rash, dermatitis, pruritus, urticaria
- Other: Painful extremities, back pain, arthralgia, muscle cramps,
myalgia, swollen joints
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