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Back to Drug index

Back to Fibrates (Antilipemics)

Name: Gemfibrozil

Pregnancy Category B

Drug classes

  • Antihyperlipidemic agent

Therapeutic actions

Inhibits peripheral lipolysis and decreases the hepatic excretion of free fatty acids; this reduces hepatic triglyceride production; inhibits synthesis of VLDL carrier apolipoprotein; decreases VLDL production; increases HDL concentration.


Hypertriglyceridemia in adult patients with triglyceride levels 750 mg/dl (type IVand V hyperlipidemia) at risk of abdominal pain and pancreatitis who do not respond to diet therapy

Reduction of coronary heart disease risk, possibly effective


Allergy to gemfibrozil, hepatic or renal dysfunction, primary biliary cirrhosis, gallbladder disease, pregnancy, lactation.

Adverse effects

  • CNS: Headache, dizziness, blurred vision, vertigo, insomnia, paresthesia, tinnitus, fatigue, malaise, syncope
  • GI: Abdominal pain, epigastric pain, diarrhea, nausea, vomiting, flatulence, dry mouth, constipation, anorexia, dyspepsia, cholelithiasis
  • Hematologic: Anemia, eosinophilia, leukopenia, hypokalemia, liver function changes, hyperglycemia
  • GU: Impairment of fertility
  • Dermatologic: Eczema, rash, dermatitis, pruritus, urticaria
  • Other: Painful extremities, back pain, arthralgia, muscle cramps, myalgia, swollen joints
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