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Back to Drug index

Back to Fibrates (Antilipemics)

Name: Gemfibrozil

Pregnancy Category B

Drug classes

  • Antihyperlipidemic agent

Therapeutic actions

Inhibits peripheral lipolysis and decreases the hepatic excretion of free fatty acids; this reduces hepatic triglyceride production; inhibits synthesis of VLDL carrier apolipoprotein; decreases VLDL production; increases HDL concentration.

Indications

Hypertriglyceridemia in adult patients with triglyceride levels 750 mg/dl (type IVand V hyperlipidemia) at risk of abdominal pain and pancreatitis who do not respond to diet therapy

Reduction of coronary heart disease risk, possibly effective

Contraindications/cautions

Allergy to gemfibrozil, hepatic or renal dysfunction, primary biliary cirrhosis, gallbladder disease, pregnancy, lactation.

Adverse effects

  • CNS: Headache, dizziness, blurred vision, vertigo, insomnia, paresthesia, tinnitus, fatigue, malaise, syncope
  • GI: Abdominal pain, epigastric pain, diarrhea, nausea, vomiting, flatulence, dry mouth, constipation, anorexia, dyspepsia, cholelithiasis
  • Hematologic: Anemia, eosinophilia, leukopenia, hypokalemia, liver function changes, hyperglycemia
  • GU: Impairment of fertility
  • Dermatologic: Eczema, rash, dermatitis, pruritus, urticaria
  • Other: Painful extremities, back pain, arthralgia, muscle cramps, myalgia, swollen joints
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