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Back to Cardiology Drug index

Back to Statins (Antilipemics)

Name: Atorvastatin

Pregnancy Category X

Drug classes of Atorvastatin

HMG-CoA inhibitors

Mechanism of action of Atorvastatin

Inhibitor of HMG-CoA reductase, the rate limiting enzyme in cholesterol synthesis (associated with increased risk of coronary artery disease), and either an increase or no change in serum HDLs (associated with decreased risk of coronary artery disease).

Indications of Atorvastatin

  1. As an adjunct to diet in the treatment of elevated total cholesterol and LDL cholesterol in patients with primary hypercholesterolemia (types IIa and IIb) whose response to dietary restriction of saturated fat and cholesterol and other nonpharmacologic measures has not been adequate.

Contraindications of Atorvastatin

  1. Allergy to atorvastatin
  2. Active liver disease
  3. Pregnancy
  4. Lactation

Grapefruit juice should not be taken with Atorvastatin (lipitor) as it may increase the serum concentrations of atorvastatin.

Adverse effects of Atorvastatin

  • CNS: Headache, blurred vision, dizziness, insomnia, fatigue, muscle cramps, cataracts
  • GI: Flatulence, abdominal pain, cramps, constipation, nausea, dyspepsia, heartburn
  • Hematologic: Elevations of CPK, alkaline phosphatase and transaminiases
  • Neuromuscular: Myopathy, rhabdomyolysis
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