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Pregnancy Category X
Drug classes of Pravastatin
Therapeutic actions of Pravastatin
Inhibits the enzyme that catalyzes the rate-limiting step in the cholesterol
synthesis pathway, resulting in a decrease in serum cholesterol, serum
LDL's (the lipids associated with the development of
coronary artery disease),
and either an increase or no change in serum HDL's (the lipids associated
with decreased risk of
Indications of Pravastatin
As an adjunct to diet in the treatment of elevated total cholesterol
and LDL cholesterol in patients with primary hypercholesterolemia (types
IIa and IIb) whose response to dietary restriction of saturated fat and
cholesterol and other nonpharmacologic measures has not been adequate.
Contraindications/cautions of Pravastatin
Contraindicated in the presence of allergy to pravastatin, fungal byproducts,
Use caution in the presence of impaired hepatic function, cataracts.
Adverse effects of Pravastatin
Headache, blurred vision,
dizziness, insomnia, fatigue, muscle cramps, cataracts
- GI: Flatulence,
abdominal pain, cramps,
- Hematologic: Elevations of
alkaline phosphatase and
- Neuromuscular: Myopathy, rhabdomyolysis
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