Pregnancy Category X
Drug classes of Simvastatin
Therapeutic actions of Simvastatin
Inhibits HMG co-enzyme A, the enzyme that catalyzes the first step in the cholesterol synthesis pathway, resulting in a decrease in serum cholesterol, serum LDLs (associated with increased risk of coronary artery disease), and either an increase or no change in serum HDLs (associated with decreased risk of coronary artery disease).
Indications of Simvastatin
As an adjunct to diet in the treatment of elevated total cholestrol and LDL cholesterol in patients with primary hypercholesterolemia (types IIa and IIb) whose response to dietary restriction of saturated fat and cholesterol and other nonpharmacologic measures has not been adequate.
Contraindications/cautions of Simvastatin
Contraindicated in the presence of allergy to simvastatin, fungal byproducts, pregnancy, lactation.
Use caution in the presence of impaired hepatic function, cataracts.
Adverse effects of Simvastatin
- CNS: Headache, asthenia
- GI: Flatulence, abdominal pain, cramps, constipation, nausea, dyspepsia, heartburn
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