| |
Back to Cardiology Drug index
Name: Isradipine
Pregnancy Category C
Drug classes
- Calcium channel-blocker
- Antihypertensive
Therapeutic actions
Inhibits the movement of calcium ions across the membranes of cardiac
and
arterial muscle cells; calcium is involved in the generation of the
action potential in specialized automatic and conducting cells in the
heart and in arterial smooth muscle and excitation-contraction
coupling
in cardiac muscle cells; inhibition of transmembrane calcium flow
results
in the depression of impulse formation in specialized cardiac
pacemaker
cells, slowing of the velocity of conduction of the cardiac impulse,
the
depression of myocardial contractility, and the dilation of coronary
arteries and arterioles and peripheral arterioles. These effects lead
to
decreased cardiac work, cardiac energy consumption, and blood
pressure.
Indications
Management of hypertension alone or in combination with thiazide-type
diuretics
Contraindications/cautions
Contraindicated in the presence of allergy to isradipine; sick sinus
syndrome, except in presence of ventricular pacemaker; heart block
(second or third degree); IHSS; cardiogenic shock, severe CHF;
pregnancy;
lactation.
Use caution in the presence of hypotension, impaired hepatic or renal
function (repeated doses may accumulate).
Adverse effects
- CNS: Dizziness, vertigo, emotional depression, sleepiness, headache
- GI: Nausea, constipation
- CV: Peripheral edema, hypotension, arrhythmias, bradycardia, AV heart
block
- Other: Muscle fatigue, diaphoresis
|
|
|
|
Are you a doctor or a nurse?
Do you want to join the Doctors Lounge online medical community?
Participate in editorial activities (publish, peer review, edit) and
give a helping hand to the largest online community of patients.
Click on the link below to see the requirements:
Doctors Lounge Membership
Application |
|
|
|
|
|
|
send
to a friend
printer
friendly version
