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Back to Cardiology Drug index
Name: Bumetanide
Pregnancy Category C
Drug classes
- Loop (high ceiling) diuretic
Therapeutic actions
Inhibits the reabsorption of sodium and chloride from the proximal and
distal renal tubules and the loop of Henle, leading to a natriuretic
diuresis.
Indications
- Edema associated with CHF, cirrhosis, renal disease
- Acute pulmonary edema (IV)
- Unlabeled use: treatment of adult nocturia
Contraindications/cautions
Allergy to bumetanide; electrolyte depletion; anuria, severe renal
failure; hepatic coma; SLE; gout; diabetes mellitus; lactation.
Adverse effects
- CNS: Asterixis, dizziness, vertigo, paresthesias, confusion, fatigue,
nystagmus, weakness, headache, drowsiness, fatigue, blurred vision,
tinnitus, irreversible hearing loss
- GI: Nausea, anorexia, vomiting, diarrhea, gastric irritation and pain,
dry mouth, acute pancreatitis, jaundice
- CV: Orthostatic hypotension, volume depletion, cardiac arrhythmias,
thrombophlebitis
- Hematologic: Hypokalemia, leukopenia, anemia, thrombocytopenia
- GU: Polyuria, nocturia, glycosuria, renal failure
- Local: Pain, phlebitis at injection site
- Other: Muscle cramps and muscle spasms, weakness, arthritic pain,
fatigue, hives, photosensitivity, rash, pruritus, sweating, nipple
tenderness
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