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Name: Bumetanide

Pregnancy Category C

Drug classes

  • Loop (high ceiling) diuretic

Therapeutic actions

Inhibits the reabsorption of sodium and chloride from the proximal and distal renal tubules and the loop of Henle, leading to a natriuretic diuresis.

Indications

  • Edema associated with CHF, cirrhosis, renal disease
  • Acute pulmonary edema (IV)
  • Unlabeled use: treatment of adult nocturia

Contraindications/cautions

Allergy to bumetanide; electrolyte depletion; anuria, severe renal failure; hepatic coma; SLE; gout; diabetes mellitus; lactation.

Adverse effects

  • CNS: Asterixis, dizziness, vertigo, paresthesias, confusion, fatigue, nystagmus, weakness, headache, drowsiness, fatigue, blurred vision, tinnitus, irreversible hearing loss
  • GI: Nausea, anorexia, vomiting, diarrhea, gastric irritation and pain, dry mouth, acute pancreatitis, jaundice
  • CV: Orthostatic hypotension, volume depletion, cardiac arrhythmias, thrombophlebitis
  • Hematologic: Hypokalemia, leukopenia, anemia, thrombocytopenia
  • GU: Polyuria, nocturia, glycosuria, renal failure
  • Local: Pain, phlebitis at injection site
  • Other: Muscle cramps and muscle spasms, weakness, arthritic pain, fatigue, hives, photosensitivity, rash, pruritus, sweating, nipple tenderness

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