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Name: Indapamide

Pregnancy Category B

Drug classes

  • Thiazide-like diuretic (actually an indoline)

Therapeutic actions

Inhibits reabsorption of sodium and chloride in distal renal tubule, increasing excretion of sodium, chloride, and water by the kidney.

Indications

  • Edema associated with CHF
  • Hypertension, as sole therapy or in combination with other antihypertensives

Unlabeled use: diabetes insipidus, especially nephrogenic diabetes insipidus

Contraindications/cautions

Contraindicated in the presence of allergy to thiazides, sulfonamides; fluid or electrolyte imbalance; renal disease (risk of azotemia); liver disease (may precipitate hepatic coma); gout (risk of precipitation of attack); SLE; glucose tolerance abnormalities, diabetes mellitus; hyperparathyroidism; manic-depressive disorder (aggravated by hypercalcemia); pregnancy; lactation.

Adverse effects

  • CNS: Dizziness, vertigo, paresthesias, weakness, headache, drowsiness, fatigue, leukopenia, thrombocytopenia, agranulocytosis, aplastic anemia, neutropenia
  • GI: Nausea, anorexia, vomiting, dry mouth, diarrhea, constipation, jaundice, hepatitis, pancreatitis
    CV: Orthostatic hypotension, venous thrombosis, volume depletion, cardiac arrhythmias, chest pain
  • GU: Polyuria, nocturia, impotence, loss of libido
  • Dermatologic: Photosensitivity, rash, purpura, exfoliative dermatitis, hives
  • Other: Muscle cramps and muscle spasms, fever, gouty attacks, flushing, weight loss, rhinorrhea

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