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Back to Cardiology Drug index
Name: Indapamide
Pregnancy Category B
Drug classes
- Thiazide-like diuretic (actually an indoline)
Therapeutic actions
Inhibits reabsorption of sodium and chloride in distal renal tubule,
increasing excretion of sodium, chloride, and water by the kidney.
Indications
- Edema associated with CHF
- Hypertension, as sole therapy or in combination with other
antihypertensives
Unlabeled use: diabetes insipidus, especially nephrogenic diabetes
insipidus
Contraindications/cautions
Contraindicated in the presence of allergy to thiazides, sulfonamides;
fluid or electrolyte imbalance; renal disease (risk of azotemia); liver
disease (may precipitate hepatic coma); gout (risk of precipitation of
attack); SLE; glucose tolerance abnormalities, diabetes mellitus;
hyperparathyroidism; manic-depressive disorder (aggravated by
hypercalcemia); pregnancy; lactation.
Adverse effects
- CNS: Dizziness, vertigo, paresthesias, weakness, headache, drowsiness,
fatigue, leukopenia, thrombocytopenia, agranulocytosis, aplastic
anemia,
neutropenia
- GI: Nausea, anorexia, vomiting, dry mouth, diarrhea, constipation,
jaundice, hepatitis, pancreatitis
CV: Orthostatic hypotension, venous thrombosis, volume depletion,
cardiac arrhythmias, chest pain
- GU: Polyuria, nocturia, impotence, loss of libido
- Dermatologic: Photosensitivity, rash, purpura, exfoliative dermatitis,
hives
- Other: Muscle cramps and muscle spasms, fever, gouty attacks,
flushing,
weight loss, rhinorrhea
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