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Back to Cardiology Drug index
Name: Isosorbide dinitrate
Pregnancy Category C
Drug classes
Therapeutic actions
Relaxes vascular smooth muscle with a resultant decrease in venous
return
and decrease in arterial blood pressure, which reduces left
ventricular
workload and decreases myocardial oxygen consumption.
Indications
Treatment and prevention of angina pectoris
Contraindications/cautions
Allergy to nitrates, severe anemia, GI hypermobility
(sustained-release
tablets), head trauma, cerebral hemorrhage, hypertrophic
cardiomyopathy,
pregnancy, lactation.
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Adverse effects
- CNS: Headache, apprehension, restlessness, weakness, vertigo,
dizziness,
faintness
- GI: Nausea, vomiting, incontinence or urine and feces, abdominal pain
- CV: Tachycardia, retrosternal discomfort, palpitations, hypotension,
syncope, collapse, postural hypotension, angina
- Dermatologic: Rash, exfoliative dermatitis, cutaneous vasodilation
with
flushing
- Other: Muscle twitching, pallor, perspiration, cold sweat
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