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Back to Cardiology Drug index

Back to Nitrates

Name: Isosorbide dinitrate

Pregnancy Category C

Drug classes

  • Antianginal drug
  • Nitrate

Therapeutic actions

Relaxes vascular smooth muscle with a resultant decrease in venous return and decrease in arterial blood pressure, which reduces left ventricular workload and decreases myocardial  oxygen consumption.


Treatment and prevention of angina pectoris


Allergy to nitrates, severe anemia, GI hypermobility (sustained-release tablets), head trauma, cerebral hemorrhage, hypertrophic cardiomyopathy, pregnancy, lactation.

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Adverse effects

  • CNS: Headache, apprehension, restlessness, weakness, vertigo, dizziness, faintness
  • GI: Nausea, vomiting, incontinence or urine and feces, abdominal pain
  • CV: Tachycardia, retrosternal discomfort, palpitations, hypotension, syncope, collapse, postural hypotension, angina
  • Dermatologic: Rash, exfoliative dermatitis, cutaneous vasodilation with flushing
  • Other: Muscle twitching, pallor, perspiration, cold sweat

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