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Pregnancy Category (not applicable)
Relaxes vascular smooth muscle; the smooth muscle of the ductus arteriosus
is especially sensitive to this action and will relax and stay open; this
is beneficial in infants who have congenital defects that restrict pulmonary
or systemic blood flow and who depend on a patent ductus arteriosus for
adequate blood oxygenation and lower body perfusion.
Palliative therapy to temporarily maintain the patency of the ductus
arteriosus until corrective or palliative surgery can be performed in
neonates with congenital heart defects who depend on a patent ductus (eg,
pulmonary atresia or stenosis, tetralogy of Fallot, coarctation of the
Contraindicated in the presence of respiratory distress syndrome.
Use caution in the presence of bleeding tendencies (drug inhibits platelet
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- CNS: Seizures, cerebral bleeding, hypothermia, jitteriness, lethargy,
- GI: Diarrhea
- CV: Bradycardia, flushing, tachycardia, hypotension, cardiac arrest,
heart block, CHF
- Respiratory: Apnea, respiratory distress
- Hematologic: Inhibited platelet aggregation, bleeding, anemia, disseminated
intravascular coagulation, hypokalemia
- Other: Cortical proliferation of the long bones (with prolonged
use, regresses after treatment is stopped), sepsis