Powered by


                    Home  |  Forums  |  Humor  |  Advertising  |  Contact
   Ask a Doctor

   News via RSS






   Forum Archives





















   Primary Care






   Other Sections


   Research Tools

   Medical Tutorials

   Medical Software




Back to Cardiology Drug index

Back to Prostaglandins

Name: Alprostadil

Pregnancy Category (not applicable)

Drug classes


Therapeutic actions

Relaxes vascular smooth muscle; the smooth muscle of the ductus arteriosus is especially sensitive to this action and will relax and stay open; this is beneficial in infants who have congenital defects that restrict pulmonary or systemic blood flow and who depend on a patent ductus arteriosus for adequate blood oxygenation and lower body perfusion.


Palliative therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates with congenital heart defects who depend on a patent ductus (eg, pulmonary atresia or stenosis, tetralogy of Fallot, coarctation of the aorta)


Contraindicated in the presence of respiratory distress syndrome.

Use caution in the presence of bleeding tendencies (drug inhibits platelet aggregation).

advertisement.gif (61x7 -- 0 bytes)

Are you a doctor or a nurse?

Do you want to join the Doctors Lounge online medical community?

Participate in editorial activities (publish, peer review, edit) and give a helping hand to the largest online community of patients.

Click on the link below to see the requirements:

Doctors Lounge Membership Application

Adverse effects

  • CNS: Seizures, cerebral bleeding, hypothermia, jitteriness, lethargy, stiffness
  • GI: Diarrhea
  • CV: Bradycardia, flushing, tachycardia, hypotension, cardiac arrest, heart block, CHF
  • Respiratory: Apnea, respiratory distress
  • Hematologic: Inhibited platelet aggregation, bleeding, anemia, disseminated intravascular coagulation, hypokalemia
  • Other: Cortical proliferation of the long bones (with prolonged use, regresses after treatment is stopped), sepsis

 advertisement.gif (61x7 -- 0 bytes)



We subscribe to the HONcode principles of the HON Foundation. Click to verify.
We subscribe to the HONcode principles. Verify here

Privacy Statement | Terms & Conditions | Editorial Board | About us
Copyright 2001-2012 DoctorsLounge. All rights reserved.