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Forum Name: Clots & Anticoagulants

Question: Factor II Prothrombin mutation

 WendyNY - Tue Oct 23, 2007 6:17 pm

I just found out I have this (tested after multiple m/c's). At this point I'm more concerned about heart/clot risk as I have other risk factors besides this clotting disorder. I had posed a question about elevated protein S levels in conjunction with this & was told the two don't have anything to do with each other. I found this from a study:

"Depletion of protein S from plasma or inhibition of protein S in plasma by monoclonal antibodies induced a 5- to 25- fold increase of prothrombin activation on the procoagulant endothelial cell matrix...."

c 1995 by The American Society of Hematology.

Just to ease my mind, doesn't this means that my elevated Protein S levels are actually lowering my prothrombin and are a protective mechanism? Or does it not work the other way around??

 Dr. Chan Lowe - Fri Nov 02, 2007 1:04 pm

User avatar Hi WendyNY,

I'm not sure that this question has actually been fully studied. Unfortunately, I would not necessarily think that the elevated protein S levels will be protective although there may be some slight protection given.

You may want to talk with a hematologist about this. They are likely to know much more about this than I do.

Sorry I can't give you much more of an answer than this.

Best wishes.

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