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Forum Name: Clots & Anticoagulants

Question: Familial Clotting Disorder


 elmonk - Sun Dec 02, 2007 2:25 pm

I am 55 and have been on Coumadin for 6 years for two episodes of multiple PEs. I have two paternal cousins who had strokes at age 38. They are also on lifelong Coumadin. My father and mother developed DVTs. My brother has now been diagnosed with DVT. Incidentally, me, my brother and cousins also have Patent Foramen Ovale. All the usual tests for hereditary factors are normal in all of us. What should we pursue, now that there is an obvious familial connection?
 Dr. Chan Lowe - Mon Dec 03, 2007 11:19 pm

User avatar Hi Elmonk,

I would recommend you see a hematologist for further testing recommendations. It clearly appears that there is a genetic component to this. I'm not sure which of the conditions you are referring to when you say major factors. There are many, many clotting disorders. The most common are Factor V leiden, prothrombin 20210 mutations, and antiphospholipid antibodies or lupus anticoagulant.

It will be very helpful to determine the cause if possible so future generations can also be aware of the condition and possibly be tested to assess their risk.

Best wishes.
 elmonk - Sun Dec 16, 2007 3:10 pm

We have already been teste for all the hereditary factors you have mentioned and they are all within normal limtis. I have been seen by a hematologist and been told there may be as yet undiscovered factors. He could not explain why this is such a problem in our family.

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