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Forum Name: Hypertension

Question: Lotrel and grapefruit

 kmm21 - Tue May 05, 2009 11:57 pm

I take lotrel 10/40. I have been eating a grapefruit daily for about two weeks. I just read that there is a side effect with grapefruit and lotrel. I have a headache, gas and chest pressure. Is this related? What should I do?
 John Kenyon, CNA - Mon May 11, 2009 10:19 pm

User avatar Hello --

Grapefruit and Lotrel (amlodipine) do not interact at all, so this is not the cause of your symptoms. Since you already suffer from elevated BP there is an increased risk of heart problems and given your symptoms I would hope you will either make an appointment with a physician (preferably a cardiologist) or at least consult with your prescribing doctor about this. If they persist or become any more severe, please just report to the nearest emergency facility and have yourself evaluated. Either the medication may be causing the symptoms or you may have some premature heart disease associated with elevated blood pressure.

It's definitely not the grapefruit in this case, unless it's simply causing acid reflux (which would be a best-case scenario). I hope this is helpful. Please follow up with us here as needed. Good luck to you.


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