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Back to Chest Drug index

Back to Antihistamines

Name: Loratidine

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Pregnancy Category C

Drug classes of Loratidine

Antihistamines (nonsedating type)

Mechanism of action of Loratidine

Competitively blocks the effects of histamine at peripheral H1 receptor sites; has anticholinergic (atropine-like) and antipruritic effects.

Indications of Loratidine

  1. Relief of symptoms associated with perennial and seasonal allergic rhinitis; vasomotor rhinitis; allergic conjunctivitis; mild, uncomplicated urticaria and angioedema
  2. Amelioration of allergic reactions to blood or plasma
  3. Dermatographism
  4. Adjunctive therapy in anaphylactic reactions

Contraindications of Loratidine

  1. Allergy to any antihistamines
  2. Narrow-angle glaucoma
  3. Stenosing peptic ulcer
  4. Symptomatic prostatic hypertrophy
  5. Asthmatic attack
  6. Bladder neck obstruction
  7. Pyloroduodenal obstruction (avoid use or use with caution as condition may be exacerbated by drug effects)
  8. Lactation
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Adverse effects of Loratidine

  • CNS: Headache, nervousness, dizziness, depression
  • GI: Appetite increase, nausea, diarrhea, abdominal pain
  • CV: Palpitation, edema
  • Respiratory: Bronchospasm, pharyngitis
  • General: Weight gain
  • Other: Fever, photosensitivity, rash, myalgia, arthralgia, angioedema

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