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 Headlines:

 
 

 

Back to Chest Drug index

Back to Antihistamines

Name: Clemastine

  Asthma News
 

Xolair reduced the rate of hospital emergency visits by 44% in patients with inadequately controlled asthma.

 

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related discussion
 

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Asthma

 
   

Pregnancy Category B

cromolyn sodium
disodium cromoglycate, cromoglicic acid, cromoglycic acid
Gastrocrom
Respiratory inhalant, nasal solution, ophthalmic solution: Intal,
Nasalcrom, Opticrom 4%
Pregnancy Category B

Drug classes
Antiasthmatic drug (prophylactic)
Antiallergic drug

Therapeutic actions
Inhibits the allergen-triggered release of histamine and slow-releasing
substance of anaphylaxis, leukotriene, from mast cells; decreases the
overall allergic response.


Indications
Respiratory inhalant: Prophylaxis of severe bronchial asthma; prevention
of exercise-induced bronchospasm
Nasal preparations: Prevention and treatment of allergic rhinitis
Ophthalmic solution: Treatment of allergic disorders (vernal
keratoconjuctivitis and conjunctivitis, giant papillary conjunctivitis,
vernal keratitis, allergic keratoconjunctivitis)
Oral use: orphan drug use-mastocytosis
Unlabeled uses: prevention of GI and systemic reactions in patients with
food allergies; treatment of eczema, dermatitis, ulcerations, urticaria
pigmentosa, chronic urticaria, hay fever, postexercise bronchospasm

Contraindications/cautions
Allergy to cromolyn, pregnancy, lactation.

Respiratory inhalant and nasal products: Impaired renal or hepatic
function.


Adverse effects

Respiratory Inhalant Product
CNS: Dizziness, headache, lacrimation
GI: Nausea, dry and irritated throat, swollen parotid glands
GU: Dysuria, frequency
Dermatologic: Urticaria, rash, angioedema, joint swelling and pain

Nebulizer Solution
GI: Abdominal pain
Respiratory: Cough, nasal congestion, wheezing, sneezing, nasal itching,
epistaxis, nose burning

Nasal Solution
CNS: Headaches
GI: Bad taste in mouth
Respiratory: Sneezing, nasal stinging or burning, nasal irritation,
epistaxis, postnasal drip
Dermatologic: Rash

Ophthalmic Solution
Local: Transient ocular stinging or burning on instillation

Oral
CNS: Dizziness, fatigue, paresthesia, headache, migraine, psychosis,
anxiety, depression, insomnia, behavior change, hallucinations, lethargy
GI: Taste perversion, diarrhea, esophagospasm, flatulence, dysphagia,
hepatic function tests abnormality, burning in the mouth and throat
Dermatologic: Flushing, urticaria, angioedema, skin erythema and burning
 

Drug classes of Clemastine

Antihistamines (sedating type)

Mechanism of action of Clemastine

Competitively blocks the effects of histamine at peripheral H1 receptor sites.

Indications of Clemastine

  1. Relief of symptoms associated with perennial and seasonal allergic rhinitis; vasomotor rhinitis; allergic conjunctivitis; mild, uncomplicated urticaria and angioedema
  2. Amelioration of allergic reactions to blood or plasma
  3. Dermatographism
  4. Adjunctive therapy in anaphylactic reactions

Contraindications of Clemastine

  1. Allergy to any antihistamines
  2. Narrow angle glaucoma
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Adverse effects of Clemastine

  • CNS: Sedation, sleepiness, dyscoordination, somnolence, headache, dizziness, nervousness
  • GI: Epigastric distress
  • CV: Palpitation, tachycardia, hypotension
  • Respiratory: Thickening of bronchial secretions
  • General: Weight gain
  • Other: Photosensitivity, rash, urticaria, angioedema
 

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