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Back to Chest Drug index
Name: Cortisone
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Xolair reduced the rate of hospital emergency visits by 44% in
patients with inadequately controlled asthma.
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 related discussion |
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Pregnancy Category C
Drug classes
- Adrenal cortical hormone
- Corticosteroid, short acting
- Hormonal agent
Therapeutic actions
Enters target cells where it has anti-inflammatory and
immunosuppressive
(glucocorticoid) and salt-retaining (mineralocorticoid) effects.
Indications
- Replacement therapy in adrenal cortical insufficiency
- Hypercalcemia associated with cancer
- Short-term management of various inflammatory and allergic disorders,
such as rheumatoid arthritis, collagen diseases (eg, SLE),
dermatologic
diseases (eg, pemphigus), status asthmaticus, and autoimmune disorders
- Hematologic disorders: thrombocytopenic purpura, erythroblastopenia
- Trichinosis with neurologic or myocardial involvement
- Ulcerative colitis, acute exacerbations of multiple sclerosis, and
palliation in some leukemias and lymphomas
Contraindications/cautions
Contraindicated in the presence of infections, especially
tuberculosis,
fungal infections, amebiasis, vaccinia and varicella, and
antibiotic-resistant infections, pregnancy, lactation.
Use caution in the presence of renal or hepatic disease;
hypothyroidism,
ulcerative colitis with impending perforation; diverticulitis; active
or
latent peptic ulcer; inflammatory bowel disease; CHF, hypertension,
thromboembolic disorders; osteoporosis; convulsive disorders; diabetes
mellitus.
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Adverse effects
- CNS: Convulsions, vertigo, headaches, pseudotumor cerebri, euphoria,
insomnia, mood swings, depression, psychosis, intracerebral
hemorrhage,
reversible cerebral atrophy in infants, cataracts, increased
intraocular
pressure, glaucoma
- GI: Peptic or esophageal ulcer, pancreatitis, abdominal distention
- CV: Hypertension, CHF, necrotizing angiitis
- Hematologic: Fluid and electrolyte disturbances, negative nitrogen
balance, increased blood sugar, glycosuria, increased serum
cholesterol,
decreased serum T3 and T4 levels
- GU: Amenorrhea, irregular menses
- MS: Muscle weakness, steroid myopathy, loss of muscle mass,
osteoporosis, spontaneous fractures
- Endocrine: Growth retardation, decreased carbohydrate tolerance,
diabetes mellitus, cushingoid state, secondary adrenocortical and
pituitary unresponsiveness
- Hypersensitivity: Anaphylactoid or hypersensitivity reactions
- Other: Impaired wound healing, petechiae, ecchymoses, increased
sweating, thin and fragile skin, acne, immunosuppression and masking
of
signs of infection, activation of latent infections including
tuberculosis, fungal and viral eye infections, pneumonia, abscess,
septic
infection, GI and GU infections
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