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Doctors Lounge - Dermatology Answers
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| audionut
- Fri Aug 13, 2010 4:38 am |
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Is 1000mg daily tetracycline use for a little over a year safe?
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| Dr.M.jagesh kamath
- Fri Aug 13, 2010 9:48 pm |
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 Hello,Long term tetracycline therapy is generally indicated in moderate to severe acne and generally coupled with topical therapy.Tetracyclines are generally well tolerated.The side effects are mild and transient in most.Tetracyclines are avoided in children and pregnant women due to the action on teeth and bone.Overgrowth of monilial organisms are common on long term therapy.Photo dermatitis is another known complication.Typically 500mg twice daily tetracycline should give good results by 3 to 6 months in acne vulgaris.After this the medication is tapered.Recurrence may mean continuance of therapy.But this also means that the bacteria may develop resistance.Also overgrowth of gram-ve organisms sometimes happen.
My answer is based on treatment of Acne and tetracycline.The long term treatment though comparatively safe has to be planned by the specialist bearing in mind the age,renal and hepatic function,CBC counts etc.
Best wishes.
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