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Back to Endocrine Diseases

Congenital adrenal hyperplasia

Congenital adrenal hyperplasia (CAH) is an autosomal recessive disease resulting from a defect in the synthesis of corticosteroids by the adrenal gland. In most cases the defect is in the enzyme 21-hydroxylase, which results in aldosterone and cortisol deficiency and an overproduction of androgens.

Common features of CAH include early masculinization of males and virilization of females.

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