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Back to Endocrine Diseases
Hyperprolactinaemia
Hyperprolactinaemia is the term given to having too high levels of
prolactin in the blood. (Normal levels are less than 580 mIU/L for
women, and less than 450 mIU/L for men.)
Causes
One cause of hyperprolactinaemia is the presence of the biologically
inactive macroprolactin in the serum. This can show up as high
prolactin in some types of tests, but is asymptomatic. Another cause
of hyperprolactinaemia is a prolactinoma, a pituitary gland tumor.
Symptoms and signs
Hyperprolactinaemia is a common cause of menstrual problems in women,
and high levels of prolactin can cause gynecomastia (breast
enlargement) in men. It can also cause galactorrhea.
The hormone prolactin is downregulated by dopamine and is upregulated
by estrogen.

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