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Back to Endocrine Diseases
Syndrome of inappropriate antidiuretic hormone (SIADH)
Clinical suspicion
Suspect when there is water retention (antidiuresis) associated with
an empty bladder and dilutional hyponatremia. There is no hypertension or
edema.
Diagnosis
Once suspected low serum sodium and osmolality accompanied by a high
urine osmolality.
Treatment
Fluid restriction.
Demethylchlortetracycline (demeclocycline) in patients unresponsive to
fluid restriction. It may cause photosensitivity.
Severe hyponatremia is treated by hypertonic saline combined with frusemide
to avoid volume overload.
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