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Back to Endocrinology Drug Index

Back to Thyroxine supplements

Name: Levothyroxine sodium

Pregnancy Category A

Drug classes

Thyroid hormone

Therapeutic actions

Increases the metabolic rate of body tissues, thereby increasing oxygen consumption; R and heart rate; rate of fat, protein, and carbohydrate metabolism; and growth and maturation.

Indications

Replacement therapy in hypothyroidism

Pituitary TSH suppression in the treatment and prevention of euthyroid goiters and in the management of thyroid cancer

Thyrotoxicosis in conjunction with antithyroid drugs and to prevent goitrogenesis, hypothyroidism, and thyrotoxicosis during pregnancy

Treatment of myxedema coma

Contraindications/cautions

Contraindicated in the presence of allergy to active or extraneous constituents of drug, thyrotoxicosis, and acute MI uncomplicated by hypothyroidism.

Use caution in the presence of Addison's disease (treatment of hypoadrenalism with corticosteroids should precede thyroid therapy) and lactation.

Adverse effects

  • Endocrine: Symptoms of hyperthyroidism
  • Dermatologic: Allergic skin reactions, partial loss of hair in first few months of therapy in children
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