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Forum Name: Endocrinology Topics

Question: Sweating related to low estradiol, low fsh, and low lh?


 carlita - Sat Mar 10, 2007 9:15 pm

I am a 27 yr old woman who has been suffering from hot flushes and generalized hyperhidrosis since age 22. I sweat badly all over my body if I am slightly hot, feel any stress or strong emotion, etc. I have seen a few dermatologists who don't really know what to do. I have seen one endocrinologist who simply gave me a pep talk and did not run any diagnostic tests.

I recently discovered that my estradiol levels are in the post menopausal reference range (<60 pmol/L). My luteinizing hormone level is <1 IU/L and my follicle stimulating hormone level is <1 IU/L, which is on the low side. My progesterone levels are 1.0 IU/L and my prolactin levels are 9 ug/L, which I think is normal.

I am currently taking Ortho Ovral as an oral contraceptive and that is my only medication currently. Are my hormone levels abnormally low for a woman taking oral contraception and could this be responsible for my sweating and heat intolerance?

My family doctor does not have much expertise in this area, so I need a specialist's opinion. Please note there does not appear to be any thyroid related problem or any kind of vitamin/mineral deficiency. My doctors have ruled out many potential causes for the hyperhidrosis.

Please offer any suggestions or recommendations for treatment.

Thank you.
 Dr. Chan Lowe - Sat Mar 10, 2007 11:32 pm

User avatar I'm by no means an expert in this area; however, your FSH, LH and estradiol levels are likely to be as expected while on oral contraceptives. LH and FSH respond to the body sensing a need for higher hormone levels. Their production is inhibited by the presence of estrogen. Estradiol is made by the ovary in the presence of LH and FSH.

Since oral contraceptives often contain different forms of estrogen (rather than estradiol), the estrogen from the pill will not be picked up by the blood test, making it appear that you have low estrogen levels. The LH and FSH are suppressed by the exogenous estrogen.

Your symptoms are compatible with estrogen deficiency, though there may be other causes as well. It is possible that your oral contraceptive may not have enough estrogen in it to suppress your symptoms. Many of the newer oral contraceptives have micro dose estrogens in them.

Here's where my knowledge ends: I do not know if your body being symptomatic from estrogen deficiency would be able to sense this and cause the ovaries to make more estrogen, thus raising your estradiol level. It is quite possible that the exogenous estrogen is a potent enough inhibitor to keep FSH and LH levels down even in the face of overall lack of sufficient estrogen.

I would recommend that you talk with your gynecologist, or perhaps with your endocrinologist again to get a more knowledgeable answer.

Hope this helps some.

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