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Forum Name: Endocrinology Topics

Question: pituitary and ACTH with CNS


 boot2aboot - Wed Feb 13, 2008 6:31 pm

i was taken to the hospital when i thought i had a stroke (body wide ataxia, fascics, muscle cramps, double vision, dizziness, fatigue.) i had the million dollar work up...Spine MRI was clean other than Degenerative Disc Disease...EMG showed slow CMAPS and large MUPS in peroneal nerves of both legs, no upper EMG done...Brain MRI detected pituitary microadenoma (.9cm,) and thyroid nodules, Heart functions fine other than bradycardia...i had low BP through the course of my hospital stay...all blood work up (ANA, CBC,Lyme, Metabolic Muscle Diseases,electrolytes, MS, hormones) were fine except my cortisol level which was 2.3...The endo ordered a three hour stim test which showed cortisol level at 25.4 after one hour... how can i be sure my cortisol levels are always OK? Could a lot of the fatigue and cramps i am experiencing be hormone related? (MY thyroid was TSH /471, Free T3 at 1.06, total T3 at 1.09, slightly elevated prolactin levels)...i do not have MRI or hormone check for another six months...should i request more aggressive treatment? i want to get back to work, but i am having a hard time with the muscle atrophy and fatigue.
 Dr. Tamer Fouad - Fri Dec 05, 2008 2:25 pm

User avatar Hi there,

I hope by now you have reached a clear diagnosis of your condition. To answer one of your questions: a chronic increase in serum glucocorticoids can lead to myopathy. This is because steroids have a direct catabolic effect on protein and ultimately lead to muscle degeneration.

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