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Doctors Lounge - Endocrinology Answers
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| joilife
- Sun Aug 08, 2010 6:07 am |
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i take 500 mil of metformin twice a day and in the last week i have become so sleepy that i cannot stay awake during the day, in the last three days i have slept almost all day and nignt and i am concearned about lactic acidosis,,or is the sleppiness just a side effect of the metformin? thanks for your help
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| Dr.M.jagesh kamath
- Fri Aug 20, 2010 9:52 am |
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 Hello,The symptoms of metformin induced lactic acidosis while nonspecific are, loss of appetite,nausea, vomiting,and altered level of consciousness and is a medical emergency.In your case it is unlikely, but may need your doctor looking out for acidosis.
Most likely causes for day time sleepiness especially,obese female diabetics would be Sleep Apnea-Hypopnea Syndrome(SAHS).Obstructive sleep apnea is disturbed sleep due to less oxygenation during night sleep and leading to excessive day time sleep.Polysomnography test is done at a sleep laboratory and could be diagnostic.This is said to be related to diabetic autonomic neuropathy.
Published online 2009 March 5. doi: 10.1371/journal.pone.0004692.
Diabetes Is an Independent Risk Factor for Severe Nocturnal Hypoxemia in Obese Patients. A Case-Control Study
Albert Lecube,#1* Gabriel Sampol,#2 Patricia Lloberes,2 Odile Romero,3 Jordi Mesa,1 Cristina Hernández,1 and Rafael Simó1
PLoS ONE. 2009; 4(3): e4692.
With my best wishes.
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