Your history and prescription record in your profile suggest you suffer from obesity and concomitant type II diabetes. Since these are both risk factors for heart disease, which you clearly also have, the goal would be to effectively manage the diabetes through diet and exercise in a very structured program supervised by medical personnel, and the best way to accomplish this would be via a cardiac rehabilitation program, if one is available in your location. You are indeed on a lot of medications now, some of which will probably be reduced or eliminated over time, while others will have to remain a part of your daily regimen, at least for a good while, if not permanently. You could get down to three or four meds eventually.
I'm not crazy about the Topamax idea for several reasons. One, it's not a use recommended by the manufacturer, and is an off-label use. When it is used to control weight it is intended to reduce binge-eating. You would do better to work with a cardiac rehab specialist in conjunction with a dietitician. The Topamax has enough potential noxious side effects to make it not worth the risk, and you really need to adopt habits that will last you a lifetime. Done right, this could resolve your diabetes, weight problems, and possibly your heart disease as well. I would look into finding a center where this sort of work is done and proceed in that direction.
I hope this is helpful. Good luck to you with this and please follow up with us here as needed.
John Kenyon, EMT, CCT
Non-invasive cardiology tech, Emergency and Critical Care technician, Critical Incident Stress Mgmt. specialist