I have not read any research about the use of phendimetrazine for depression. However, this drug is similar to what is known on the street as "speed", or medically known as amphetamine. We know that medications such as these (known as anorectic agents) improve people's mood over the short term, but they quickly lose their effect, become addictive, requiring increasing doses to improve mood, and in the long run cause worsened depression and severe consequences of addiction. be very careful, I would not use this drug to help your depression, but would talk to your psychiatrist about other alternatives. I will check to see if there is any research about its use in depression that I am unaware of, and you can check in with me if you like. Good luck!
-Eliot Seigle MD