It is a VERY bad idea for people with
depression to consume alcohol because it is a depressant and makes your symptoms worse, after the "buzz" wears off.
Effexor "adjusts" your brain chemistry to give you relief of your symptoms. If you drink with it, you are also adjusting your chemicals. The consequences are usually worse
depression that can last for several days after the drinking. 10 beers is very excessive! If you are going to be drinking heavily, even on weekends, it would be a good idea to discuss the risks with your doctor.