There are some things to consider with this knee
pain. Most importantly is a deep vein thrombosis (DVT). Risk factors for DVT include sedentary positions (hospital stays, prolonged travel in plane or car, orthopedic and other surgery), pregnancy, hx of cancer, family or personal hx of clotting disorders. Signs may include swelling,
pain, redness in the calf. Low probability of DVT may warrant a blood test called BNP whereas a higher probability for DVT may warrant venous doppler ultrasound test.
Other possible diagnosis include:
Baker's cyst (benign cyst in the posterior knee ie back portion of the knee)
Internal knee ligament damage
Internal knee cartiledge damage
Tendon strain or sprain (e.g. hamstring)
It is important to see a physician who will evaluate the knee and quickly determine the probability of DVT with appropriate testing. Otherwise orthopedic considerations will be made.