There seem to be a connection between your symptoms. First, your depression issue, could be related to your over-weight, diabetes, and hypothyroid state. Even though you are taking thyroid supplements, it could be that your synthroid dose is not sufficient, though the dose you mentioned seemed relatively high. So how soon did your doctor check your thyroid test after he put you on this synthroid dose?
Second the pain you are having could be due to neuropathy which can be caused bt diabetes. It is one of the very common complications of diabetes seen in patients.
How well is your diabetes controlled, this is a main key in your case. Is your glucophage controlling your blood sugar?
I recoomend that you see an endocrinologist, and address your thyroid and diabetes issues. The pain you have could be controlled if your diabetes is controlled, and the depression could be reveresed or lessened with the control of your thyroid dysfunction.
thank you very much, and i hope you feel better soon. Let me know if you have additional questions.
Riham Zein, Pharm.D., Ph.D.
Clinical Pharmacy Specialist