I am 34 years old, female, was diagnosed with Hashimoto's disease in 96, weighed over 200 lbs and daily life was a chore & just a lot of pain. I lost the weight easy and felt better than I ever had mentally & physically with the treatment of synthroid. I maintained a weight between 125-135 for years and lived a normal life. (my height is 5'2, well I am 5'1, I some how managed to lose a whole inch in one year) I belived I had the condition under control until Jan. 2007. 2007 has been terror, I caught chicken pox, had pneumonia twice, had some nasty virus, terrible pain everywhere-my bones hurt and they cant give me enough levothyroxine to even get close to where I am supposed to be. Doc says he doesnt want to raise the levo anymore. In ten months my dose, which for years was 200MCG( between 175 & 250) has went to 350MCG and its not changed my levels this year. It is almost like my body isn’t absorbing the medicine, it simply quit working. All my original symptoms are back with a vengeance, weight gain, pain, I am moody & down, seems like there is more pain now.. I am not exaggerating when I tell you this: I have gone from 133lbs in Jan 2007 to 199lbs in Nov 2007. My thyroid gland is not enlarged, my medication has increased in the last year and my thyroid levels didnt change, which is weird. I follow a routine with my medicine, I have taken it the same way (so I remember) for years. Is it possible that I have a tolerance or is it something bigger?