Vasopressin Mystery?

Moderators: Radiodiagnosis Team, Primary Care Team, Cardiology Team

Forum rules
YOUR POST WILL REQUIRE APPROVAL - READ: Doctors Lounge Forum Rules and Regulations
• Use a precise title for your question otherwise it will NOT be approved.
• Do not post the same question more than once & maintain related posts in original thread.
• Do not use your real name or identifiable information - You can't edit/delete your post.
AMH61805
Guest
Posts: 1
Joined: Sun Aug 01, 2010 6:55 pm
Gender: Female

Vasopressin Mystery?

Postby AMH61805 » Sun Aug 01, 2010 7:17 pm

My 22mth old daughter was being tested for DI, because she was always thirsty, and uriniating large amounts. She had the water deprivation test. Throughout the test, her nephrologist was very pleased with the results he was getting, and said he was 99% sure that everything was fine, and she definitely didn't have DI. However, the full report will be back in 3-4wks.

I recieved a call that just like the nephrologist stated before, her urine and blood was concentrated like it should be, BUT somehow her vasopressin levels were almost non-exsistent. They should be normal as well. I was told that the renal team will be conversing with the endocrinology team, and getting back to me, since this is "perplexing."

My question is, how could her concentration be so normal, if there was no vasopressin? What is helping her concentrate? Is this a sign there is something wrong with her pitituary or hypothalmus? (excuse the spelling)

I know the doctors will explain things to me, but I hate going in blind, and I need something to go on here! Any help would be appreciated! Thank you!

User avatar
Dr.M.jagesh kamath
Medical Doctor
Posts: 1303
Joined: Mon Aug 03, 2009 7:24 am
Gender: Male

Re: Vasopressin Mystery?

Postby Dr.M.jagesh kamath » Fri Aug 13, 2010 11:38 am

Hello,Why the child has passed the water deprivation test despite deficient in AVP(ArginineVasoPressin)?Obviously there must be some vasopressin like substance.In condition(Which is very rare)Autosomal Recessive Familial Diabetes Insipidus the parentsare normal to water deprivation.The child remains aysmptomatic for the first year with no normal AVP. But there is a compensatory response from a mutated hormone Leu-AVP.Measured with radioimmunoassay the levels were increased 30 times normal,thereby suggesting that unknown mechanisms might partially compensate the deficiency of AVP in very young children.
(Ref-Human Molecular Genetics Volume 8, Number 7 Pp. 1303-1307)- Autosomal Recessive Familial Neurohypophyseal Diabetes Insipidus with Continued Secretion of Mutant Weakly Active Vasopressin.
Michael D. Willcutts, Eric Felner and Perrin C. White+
Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9063, USA

Hope this information is useful in your discussions.Best wishes.
Dr.M.Jagesh kamath MBBS. Dvd Consultant dermatologist


Return to “Endocrinology Topics”



Who is online

Users browsing this forum: No registered users and 2 guests

advertisement.gif (61x7 -- 0 bytes)
 
 



We subscribe to the HONcode principles of the HON Foundation. Click to verify.
We subscribe to the HONcode principles. Verify here

Privacy Statement | Terms & Conditions | Editorial Board | About us
Copyright © 2001-2016 Doctors Lounge. All rights reserved.