Hello,
Alkaline phosphatase ALP is an enzyme mainly synthesized in the liver and bone and to a lesser extent in the intestines and kidneys. During pregnancy the placenta becomes another source for LAP.
Normal level in adults is in the range of 20 to 140 IU/L (international units per liter).
Very high levels of ALP are seen in heptobilliary disorders, like
hepatitis, fatty liver,
cirrhosis, gallstones,and cancer. Levels are aslo high in bone diseases and during the healing of a bone fracture.
Infections, certain types of
anemia and endocrine problems may raise ALP level. Medications that have an effect on the liver may also cause elevation in ALP level like some
antibiotics, oral antidiabetics, birth control pills, analgecis, and
antidepressants.
Low levels are commonly seen in patients with chronic diseases that result in malnutrition and low protien levels. Low levels are also seen in individuals with high Vitamine D level or low Vitamine C level as well as hypomagnesemia.
It is important to refer your results to the normal range of the lab where the test was done.
A single abnormal test in otherwise normal clinical and laboratory findings, makes repeating the test reasonable.
I advise you to follow up with your doctor and to avoid any medications before doing the test.
Hope you find this information useful.
Best regards.
This answer does not substitute for direct medical consultation.
Dr. Safaa Mahmoud.
MB BCh, MSc Internal Medicine. MD Medical Oncology.
PhD Experimental Medicine and Biochemical Science.
