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Name: Aluminum Carbonate Gel
Pregnancy Category C
Drug classes
Antacid
Mechanism of action of aluminum carbonate gel
Neutralizes or reduces gastric acidity, resulting in an increase in
the pH of the stomach and duodenal bulb and inhibiting the proteolytic
activity of pepsin, which protects the lining of the stomach and
duodenum; binds with phosphate ions in the intestine to form insoluble
aluminum-phosphate complexes, lowering phosphate in hyperphosphatemia
and chronic renal failure but may cause hypophosphatemia in other
states.
Indications
- Symptomatic relief of upset stomach associated with hyperacidity
- Hyperacidity associated with peptic ulcer, gastritis, peptic
esophagitis, gastric hyperacidity, hiatal hernia
- Treatment, control, or management of hyperphosphatemia-aluminum
carbonate
- Prevention of formation of phosphate urinary stones, used in
conjunction with a low-phosphate diet-aluminum carbonate
- Unlabeled use for aluminum hydroxide: prophylaxis of GI
bleeding, stress ulcer; reduction of phosphate absorption in
hyperphosphatemia in patients with chronic renal failure
Contraindications/cautions
- Allergy to aluminum products
- Gastric outlet destruction
- Hypertension
- CHF
- Hypophosphatemia
- Lactation
Adverse effects of aluminum carbonate gel
- GI: Constipation; intestinal
obstruction, decreased absorption of fluoride, accumulation of
aluminum in serum, bone, and CNS
- MS: Osteomalacia and chronic
phosphate deficiency with bone pain, malaise, muscular weakness
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