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Name: Sucralfate
Pregnancy Category B
Drug classes
Therapeutic actions
Forms an ulcer-adherent complex at duodenal ulcer sites, protecting
the
ulcer against acid, pepsin, and bile salts, thereby promoting ulcer
healing; also inhibits pepsin activity in gastric juices.
Indications
Short-term treatment of duodenal ulcers, up to 8 wk
Maintenance therapy for duodenal ulcer patients at reduced dosage
after
healing has occurred
Unlabeled uses: accelerates healing of gastric ulcers, treatment of
NSAID- or aspirin-induced GI symptoms and GI damage, prevention of
stress
ulcers in critically ill patients
Orphan drug use: treatment of oral and esophageal ulcers due to
radiation, chemotherapy, and sclerotherapy
Contraindications/cautions
Allergy to sucralfate, chronic renal failure/dialysis (buildup of
aluminum may occur if taken in conjunction with aluminum-containing
products), pregnancy, lactation.
Adverse effects
- CNS: Dizziness, sleeplessness, vertigo
- GI: Constipation, diarrhea, nausea, indigestion, gastric discomfort,
dry
mouth
- Dermatologic: Rash, pruritus
- Other: Back pain
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