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Back to GIT prokinetic drugs

Name: Cisapride

IMPORTANT NOTE: WITHDRAWAL FROM US MARKET. CISAPRIDE IS AVAILABLE IN THE U.S. VIA LIMITED ACCESS PROTOCOL ONLY.

Pregnancy Category C

Drug classes

• Prokinetic agent
• GI drug

Therapeutic actions

Increases the release of acetylcholine in the myenteric plexus; thus, improves GI motility with little to no dopaminergic action.

Indications

Symptomatic treatment of nocturnal heartburn due to gastroesophageal reflux disease

Contraindications/cautions

Allergy to cisapride, gallbladder disease, GI hemorrhage, GI obstruction,  pregnancy, lactation, prolonged Q-T interval.

Adverse effects

• CNS: Headache, fatigue, somnolence
• GI: Abdominal pain, diarrhea, constipation, nausea, vomiting, borborygamus, bloating
• CV: Serious cardiac arrhythmiaswhen used in combination drug regimens
• Respiratory: Rhinitis, sinusitis, cough-ing, upper respiratory infections

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