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Forum Name: Gastroenterology Topics

Question: COX 1 & 2 Inhibitor


 wapiti_of_oregon - Sun Mar 16, 2008 11:19 pm

I have been doing some in depth research on this new found Mangosteen supplement in its whole form pureed. I did a med-line search at http://www.pubmed.gov to check into the studies that I was told existed and found that gamma-mangostin competitively inhibited the activities of both COX-1 and -2 according to study 34 of 44 on "Mangosteen". My question is whether continued use of a COX 1& 2 inhibitor over the long term will cause damage to my system or to my kids system. I am 40 and my children are 3 and 9 respectively.


Cordially,

Concerned Parent
 Dr. A. Madia - Mon Apr 07, 2008 12:14 pm

User avatar Hi,

Continuous usage of Cox-1 and Cox-2 inhibitors not only are a threat to your kidneys but they also increases the chances of getting a heart attack. On this last count some of the Cox-2 inhibitors even have been withdrawn from the market.

As far as Mangosteen is concerned, the supposed benefits are not yet proven. One may eat the whole fruit in its original form for its asthetic culinary value.

Apurva

References:

1. http://en.wikipedia.org/wiki/Mangosteen

2. http://www.fda.gov/cder/drug/advisory/COX2.htm

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