Doctors Lounge - Gastroenterology Answers
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Forum Name: Gastroenterology Topics
Question: digestive tract & serotonin
|shoejr - Thu Jun 26, 2003 9:28 pm||
Can someone tell me what the correlation is between the digestive tract and serotonin?
What are the symptoms if the seratonin level is not what it should be?
|Dr. Safaa Mahmoud - Sat Jun 28, 2003 3:16 am||
Serotonin affects several GI motor and sensory functions. Motor, sensory, or chemical stimuli may precipitate the release of 5-HT, which binds to 5-HT receptors localized on vagal and spinal afferents and leads to a cascade of events that may affect the modulation of colonic tone, acceleration of gastric emptying, pan-gut transit, or gastric accommodation.
Excess release of serotonin in the gut is known in a syndrome called carcinoid syndrome. In carcinoid diarrhoea accelerated emptying of the proximal colon and a reduction in its volume is the main feature of the disease effect in GIT.
more informations about possible diseases caused by excess or altered serotonin level can be found in these sites
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