Advertisement

 

doctorslounge.com

 
Powered by
Careerbuilder

 

                    Home  |  Forums  |  Humor  |  Advertising  |  Contact
   Ask a Doctor

   News via RSS

   Newsletter

   Home

   News

   Conferences

   CME

   Forum Archives

   Diseases

   Symptoms

   Labs

   Procedures

   Drugs

   Links

advertisement.gif (61x7 -- 0 bytes)

   Specialties

   Cardiology

   Dermatology

   Endocrinology

   Fertility

   Gastroenterology

   Gynecology

   Hematology

   Infections

   Nephrology

   Neurology

   Oncology

   Orthopedics

   Pediatrics

   Pharmacy

   Primary Care

   Psychiatry

   Pulmonology

   Rheumatology

   Surgery

   Urology

   Other Sections

   Membership

   Research Tools

   Medical Tutorials

   Medical Software

     
 
 

 Headlines:

 
 
 
Last Updated: Jun 12, 2009 - 3:53:09 PM

Rifaximin antibiotic improves symptoms in IBS patients
   
American College of Physicians
Oct 22, 2006 - 10:41:53 PM
Email this article
 Printer friendly page

PHILADELPHIA, October 17, 2006 A new study found that patients reported greater global improvements in irritable bowel syndrome (IBS) symptoms and less bloating after taking rifaximin than patients taking placebo. The randomized, double-blind study is the first to demonstrate a sustained benefit of an antibiotic for IBS symptoms after treatment is stopped.

The study, "The Effect of a Nonabsorbed Oral Antibiotic (Rifaximin) on the Symptoms of the Irritable Bowl Syndrome," is published in the October 17, 2006, issue of Annals of Internal Medicine.

IBS is one of the most common chronic medical conditions affecting about 15 to 20 percent of the population. Its cause is unknown but some IBS patients exhibit an overabundance of bacteria in the small bowel of the colon.

"This is the first possible treatment for the potential causative factors of IBS," said Mark Pimentel, MD, FRCP(C), Director, GI Motility Program, Cedars-Sinai Medical Center, the study's lead author. "Patients can take the antibiotic for a brief period of time and experience benefit for ten weeks."

In the study, 87 patients with IBS between the ages of 18 and 65 received 1200 mg of rifaximin (an antibiotic that works in the gut without being absorbed into the blood stream) a day or a placebo for 10 days. Patients reported their symptoms for the next 10 weeks.

More than 50 percent improvement in symptoms was reported by more patients who took rifaximin (37.2 percent) than by those who took placebo (15 percent). However, the researchers did not detect a difference in symptoms of diarrhea or constipation. Rifaximin is FDA approved for the treatment of travelers' diarrhea.

The nonabsorbed antibiotic seems to cause few side effects, another benefit for patients.

"Rifaximin doesn't get into the blood stream and interact with other medications," Dr. Pimentel said.

The drug helped patient Cynthia Greenspan get her life back.

"After the first five days of taking the medication, I started feeling better," said Greenspan. "After 10 days, I couldn't believe how much better I felt."

The researchers caution that while the study demonstrates improvement for a relatively small group of IBS patients, side effects may be difficult to assess in such a small study when considering the potentially large patient population with IBS. A larger and longer study is necessary to evaluate the effects of treatment for other symptoms, such as constipation.

In a separate editorial, Douglas A. Drossman, M.D., wrote, "Demonstrating benefit from a short course of an antibiotic for a sustained period of time in unselected patients with IBS is certainly novel and important."

Source:

American College of Physicians.

 
Top of Page

Email this article
Printer friendly page

advertisement.gif (61x7 -- 0 bytes)
 

Are you a doctor or a nurse?

Do you want to join the Doctors Lounge online medical community?

Participate in editorial activities (publish, peer review, edit) and give a helping hand to the largest online community of patients.

Click on the link below to see the requirements:

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 



We subscribe to the HONcode principles of the HON Foundation. Click to verify.
We subscribe to the HONcode principles. Verify here

Privacy Statement | Terms & Conditions | Editorial Board | About us
Copyright 2001-2007 The Doctors Lounge. All rights reserved.