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Name: Medroxyprogesterone acetate
Pregnancy Category X
- Hormonal agent
- Therapeutic actions
Progesterone derivative; endogenous progesterone transforms
endometrium into secretory endometrium; inhibits the secretion of
pituitary gonadotropins, which prevents follicular maturation and
ovulation; inhibits spontaneous uterine contraction.
Treatment of secondary amenorrhea (oral)
Abnormal uterine bleeding due to hormonal imbalance in the absence of
organic pathology (oral)
Adjunctive therapy and palliative treatment of inoperable, recurrent,
metastatic endometrial carcinoma or renal carcinoma (parenteral)
Unlabeled use for depot form: long-acting contraceptive, treatment of
Contraindicated in the presence of allergy to progestins;
thrombophlebitis, thromboembolic disorders, cerebral hemorrhage or
history of these conditions; hepatic disease, carcinoma of the breast
genital organs, undiagnosed vaginal bleeding, missed abortion;
(fetal abnormalities, including masculinization of the female fetus
been reported); lactation.
Use caution in the presence of epilepsy, migraine, asthma, cardiac or
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- CNS: Sudden, partial, or complete loss of vision; proptosis, diplopia,
migraine, precipitation of acute intermittent porphyria, mental
depression, pyrexia, insomnia, somnolence
- GI: Cholestatic jaundice, nausea
- CV: Thrombophlebitis, cerebrovascular disorders, retinal thrombosis,
pulmonary embolism, thromboembolic and thrombotic disease, increased
- GU: Breakthrough bleeding, spotting, change in menstrual flow,
amenorrhea, changes in cervical erosion and cervical secretions,
tenderness and secretion
- Dermatologic: Rash with or without pruritus, acne, melasma or chloasma,
alopecia, hirsutism, photosensitivity
- General: Fluid retention, edema, increase or decrease in weight
- Other: Decreased glucose tolerance