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Back to Drug index
Heparin calcium injection
Calciparine
heparin sodium injection
Lipo-Hepin, Liquaemin Sodium
heparin sodium and 0.9% sodium chloride, heparin sodium lock flush solution
Heparin Lock Flush, Hep-Lock
Pregnancy Category C
Drug classes
Unfractionated heparin
Anticoagulant
Mechanism of action
Inhibits thrombus and clot formation by blocking the conversion of prothrombin
to thrombin and fibrinogen to fibrin, the final steps in the clotting process.
Indications
- Prevention and treatment of venous thrombosis and pulmonary embolism
- Treatment of atrial fibrillation with embolization
- Diagnosis and treatment of disseminated intravascular coagulation
- Prevention of clotting in blood samples and heparin lock sets and
during dialysis procedures
Unlabeled uses: adjunct in therapy of coronary occlusion with acute MI,
prevention of left ventricular thrombi and CVA post-MI, prevention of cerebral
thrombosis in the evolving stroke
Contraindications
- Hypersensitivity to heparin
- Severe thrombocytopenia
- Uncontrolled bleeding
- Any patient who cannot be monitored regularly with blood coagulation
tests
- Labor and immediate postpartum period
- Women older than 60 y are at high risk for hemorrhaging
- Dysbetalipoproteinemia
- Recent surgery or injury
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Adverse effects
- Hematologic: Hemorrhage; bruising;
thrombocytopenia; elevated SGOT, SGPT levels, hyperkalemia
- Dermatologic: Loss of hair
- Hypersensitivity: Chills, fever,
urticaria, asthma
- Other: Osteoporosis, suppression
of renal function (long-term, high-dose therapy)
Treatment of overdose
Protamine sulfate (1% solution). Each mg of protamine neutralizes 100
USP heparin U. Give very slowly IV over 10 min, not to exceed 50 mg. Establish
dose based on blood coagulation studies
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