Advertisement

 

doctorslounge.com

 
Powered by
Careerbuilder

 

                    Home  |  Forums  |  Humor  |  Advertising  |  Contact
   Ask a Doctor

   News via RSS

   Newsletter

   Hematology

   News

 

 Conferences


   CME

   Forum Archives

   Diseases

   Symptoms

   Labs

   Procedures

   Drugs

   Links

advertisement.gif (61x7 -- 0 bytes)

   Specialties

   Cardiology

   Dermatology

   Endocrinology

   Fertility

   Gastroenterology

   Gynecology

   Hematology

   Infections

   Nephrology

   Neurology

   Oncology

   Orthopedics

   Pediatrics

   Pharmacy

   Primary Care

   Psychiatry

   Pulmonology

   Rheumatology

   Surgery

   Urology

   Other Sections

   Membership

   Research Tools

   Medical Tutorials

   Medical Software

     
 
 

 Headlines:

 
 
 

The Doctors Lounge - Hematology Answers

"The information provided on www.doctorslounge.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician."

Back to Hematology Answers List

Forum Name: Hematology Topics

Question: Dilantin causing high RBC in Urine?


shergeune - Tue Jan 10, 2006 3:15 am

Thank youf or taking the time to read my post. I am a 26 year old man, 150 lbs., 5'10". I am currently on Dilantin for Epilepsy. I take 400 mg on even days, 500 mg on odd days. I was recently declined life insurance due to a high level on an "RBC Micro Exam" test. Here are my urinalysis results:

Test Name
Glucose quantitative 0. 01 gm%
Gcast Micro Exam 0/40 LPF
Hcast Micro Exam 0
RBC Micro Exam 214 HPF
WBC Micro Exam 1/HPF
Cotinine NEG
Protein 15
Urine Temp. 95. 0 F
Adult Creatinine 224. 0 mg/dl
Adulterant PH 5. 7
NO LIPEMIA
NO HEMOLYSIS

Is this RBC result something that I should be really worried about, or likely a result of Dilantin at work? Any information would be greatly appreciated.

Thank you.
R. Fardoun, Pharm D - Mon Jan 23, 2006 5:50 pm

Hello

based on the numbers you have provided, you have microscopic Hematuria , which is presence of red blood cells in urine

there are in general many different causes of it:

1) Pre-Renal :Coagulopathies - TTP, Hemophilia , Wilm's Tumor ,
Sickle Cell Disease, Collagen Vascular Disease, and Vasculitis

2) Renal :
Nonglomerular: Pyelonephritis , AVMs, Neoplasms,Tuberculosis , Polycystic Kidney
and Glomerular: Alport's Syndrome, Berger's Disease, Lupus nephritis, Benign familial hematuria , AVMs , Vasculitits , glomerulonephritis

3) Post Renal

Renal Stones, , neoplasms , Uretrhritis , Cystitis ,BPH/prostatitis
Eididymititis

Additional possible causes are :
False Positives:
Vaginal bleeding
Hemoglobinuria
Foods - beets, black berries, fava beens, rhubarb

and importantly especially in your case:

Medications - quinidine, dilantin, rifamipin, sulfasalazine, phenanzopyridine, phenothiazine

Physiologic Causes - Exercise, Fever, trauma

so as I mentioned above, dilantin can cause false positive microscopic hematuria, however, if this symptom continues to bother you, or if you have any additional concerns, you may discuss it with your doctor,

if the positive RBC test in your urine turn out to be false positive, your doctor may want to persue some work up modalities: which can include the following:

IVP
Renal Ultrasound
Cystoscopy
Sickle Cell testing - including r/o sickle cell trait
24hour urine for uric acid and calcium
CBC
Urine cytology - to evaluate for transitional cell CA
Sedimentation Rate
PPD
Coagulation testing
BMP

thank you very much and I hope you always feel better.

Check a doctor's response to similar questions

send to a friend

 

advertisement.gif (61x7 -- 0 bytes)
 

Are you a doctor or a nurse?

Do you want to join the Doctors Lounge online medical community?

Participate in editorial activities (publish, peer review, edit) and give a helping hand to the largest online community of patients.

Click on the link below to see the requirements:

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 



We subscribe to the HONcode principles of the HON Foundation. Click to verify.
We subscribe to the HONcode principles. Verify here

Privacy Statement | Terms & Conditions | Editorial Board | About us
Copyright © 2001-2007 The Doctors Lounge. All rights reserved.