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Forum Name: Hematology Topics

Question: Hemoglobin Hasheron


 SartellShark - Thu Jan 25, 2007 11:30 am

I recently was told of a family member (under 1 year) who may have this mutation. Unfortunately, there is very little information about it on the web.

Can anyone describe what it is, the symptoms, possible long term effects?

Thanks
Ken
 Dr. Chan Lowe - Sat Mar 17, 2007 6:11 am

User avatar I was not able to find much about this either. From what I was able to find, Hemoglobin Hasharon is a variant of hemoglobin that is less stable than its normal counterparts. As such, those that are carriers of this hemoglobin typically will have a mild anemia as the red blood cells containing this hemoglobin are less stable than the other cells.

Patients with carrier status have one copy of the gene for Hemoglobin Hasharon and one normal copy. In production, the normal hemoglobin production typically out does the abnormal hemoglobin so the anemia is mild.

I was unable find information on the homozygous state. Many of these types of mutations are not good oxygen carriers so the paitents may be dependent on blood transfusions. I was unable to confirm any of this information regarding Hemoglobin Hasharon.

Hope this helps a little. I'll keep looking to see if I can find more.

Best wishes.
 Marceline F, RN - Sun Mar 18, 2007 1:34 am

User avatar Dear sartelSark,
Maybe this link could be of help:

http://www.ggc.org/question.html

(Greenwood Genetics Center)

Also try Metacrawler.com or Search.com using "Hb Hasharon".

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