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Forum Name: Hematology Topics

Question: Complement C8 def, Vitamin D def, and neutropenia

 lishbug72 - Sat Aug 21, 2010 11:39 pm

I was diagnosed with neutropenia (of unknown cause) 5 yrs. ago. 4 months ago, I was diagnosed with a C8 deficiency and a fairly severe Vitamin D def. I have been on Vitamin D 50,000 iu per week, but the Vitamin D level is still below normal.
My question is: Is there a disorder that involves neutropenia, C-8 deficiency, and Vitamin D deficiency?
 Dr.M.jagesh kamath - Tue Aug 24, 2010 5:08 am

User avatar Hello Lishbug72,Having gone through your symptoms let me confess my inability to get a diagnosis of a specific syndrome with all these features.However since your history does not indicate recurrent infections in the last 5 years it is quite possible you have chronic benign neutropenia or chronic idiopathic neutropenia.
With relation to your Vitamin D deficiency the article quoted down may be of interest from the therapy point of view.
Alendronate reduces serum TNFa and IL-1ß, increases neutrophil counts, and improves bone mineral density and bone metabolism indices in patients with chronic idiopathic neutropenia (CIN)-associated osteopenia/osteoporosis
(Helen A. Papadaki, Christos Tsatsanis, Anna Christoforidou, Niki Malliaraki, Maria Psyllaki, Charis Pontikoglou, Maria Miliaki, Andrew N. Margioris and George D. Eliopoulos)
Volume 22, Number 6, 577-587, DOI: 10.1007/s00774-004-0526-y
Will get back to you again soon.Best wishes.


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