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Forum Name: Hematology Topics

Question: Increased lymphocytes, monocytes


 bigguy - Mon Aug 29, 2005 4:30 pm

I received the results of my blood work and had three high items
Triglycerides 212 Total Chol- 176 HDL 40 LDL 94

Aboslute Lymphocytes 4753
Absolute Monocytes 1067

Everything else was in range....I'm 41 and a big guy 6'7" 440lbs

Any help would be greatly appreciated. Thanks.
 Dr. Tamer Fouad - Thu Jan 26, 2006 4:04 pm

User avatar Hello,

Lymphocytes are small, mononuclear cells that migrate to areas of inflammation in both early and late stages of the process. They play an important role in immunologic reactions.

Normal lymphocyte count is in the rage between 16-45% of white blood cells (WBCs). Increased lymphocytes (lymphocytosis) in adults is defined as an absolute lymphocyte count greater than 4,000/mm3.

Lymphocytosis can be either primary or secondary. The reactive, or secondary, lymphocytoses are conditions that involve absolute increases in lymphocytes caused by physiologic or pathophysiologic responses to infection (especially viral), inflammation, toxins, cytokines, or unknown agents.

Lymphocytosis is also associated with stress and consequent release of epinephrine, such as that seen in patients who have had cardiovascular collapse, septic shock, sickle cell crisis, status epilepticus, trauma, major surgery, drug reactions, or hypersensitivity. Persistent lymphocytosis may be seen in patients with autoimmune disorders, sarcoidosis, hyposplenism, or cancer and in those who are long-term cigarette smokers.

Primary lymphocytosis, often called lymphoproliferative disease, include the leukemias, the lymphomas, and monoclonal B cell lymphocytosis.

On the other hand, monocytosis (increased monocytes) may occur in infectious protozoal diseases (malaria, kala-azar, trypanosomiasis), rickettsial (Rocky Mountain spotted fever, typhus), bacterial infections (subacute bacterial endocarditis, tuberculosis, brucellosis, syphilis).

It may also arise in inflammatory/immune ulcerative colitis, regional enteritis, systemic lupus erythematosus, sarcoidosis.

Congenital Gaucher disease can lead to monocytosis.

Neoplastic monocytic leukemia, myeloid metaplasia, recovery from agranulocytosis can all lead to increased level of monocytes.

If your counts are still high it may be advisable to consult a hematologist. A bone marrow biopsy may be recommended.

Best regards.

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