Create Account | Sign In: Author or Forum

 
 
News  |  Journals  |  Conferences  |  Blogs  |  Articles  |  Forums  |  Twitter    
 

 Headlines:

 

Category: Pathology | Rheumatology | Journal

Back to Journal Articles

Gut Bacteria Linked to Autoimmune Arthritis in Mice

Last Updated: June 23, 2010.

 

Introduction of bacteria leads to production of autoantibodies, rapid development of arthritis

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
The introduction of gut bacteria into mice prone to developing arthritis and previously housed in germ-free conditions leads to rapid onset of the condition, according to research published online June 17 in Immunity.

WEDNESDAY, June 23 (HealthDay News) -- The introduction of gut bacteria into mice prone to developing arthritis and previously housed in germ-free conditions leads to rapid onset of the condition, according to research published online June 17 in Immunity.

Hsin-Jung Wu, Ph.D., of the Harvard Medical School in Boston, and colleagues analyzed data from K/BxN mice, which are susceptible to developing arthritis.

The researchers found that arthritis was reduced in mice under germ-free conditions, with reductions in serum autoantibody titers, germinal centers, and autoantibody-secreting cells and T helper 17 (Th17) cells in the spleen. In specific-pathogen-free mice, neutralizing interleukin-17 prevented the development of arthritis. Systemic deficiencies in germ-free mice were related to a loss of Th17 cells from the lamina propria of the small intestine, and introducing segmented filamentous bacteria into germ-free animals began the production of autoantibodies and rapidly led to arthritis.

"Because of the relatively high rate of discordance of human rheumatoid arthritis in monozygotic twins, the role of microbes in this disorder has been of great interest, although the conclusions have often been contentious. Only of late has some of the focus shifted to the potential influence of microbial commensals," the authors write. "Clearly, this is an area that merits further exploration, which will probably need to partner with studies on animal models to establish causality, permit mechanistic dissection, and allow preclinical evaluation of suggested therapeutic strategies."

Amgen Inc. provided mice used in the study.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2010 HealthDay. All rights reserved.


Previous: European League Against Rheumatism, June 16-19, 2010 Next: ENDO: High Normal Thyroid Levels Linked to Miscarriage

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.