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Category: Pharmacy | Monthly Briefing

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June 2010 Briefing - Pharmacy

Last Updated: July 01, 2010.

 

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for June 2010. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Group of Older Men Have Cardio Events With Testosterone Gel

WEDNESDAY, June 30 (HealthDay News) -- Older men with limited mobility have improved muscle strength but an increased risk of cardiovascular events when they receive testosterone gel supplementation, according to research published online June 30 in the New England Journal of Medicine.

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Cyclosporine After Transplant Tied to De Novo Cancer Risk

WEDNESDAY, June 30 (HealthDay News) -- Immunosuppressive treatment with cyclosporine A (CsA), rather than tacrolimus (TAC), with dose level monitoring two hours post-dosing (C2 monitoring) or in patients age 50 or younger appears to have a significant association with the development of de novo cancer after liver transplantation, according to research published in the July issue of Liver Transplantation.

Abstract
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Many Breast Cancer Patients Don't Adhere to Therapy

WEDNESDAY, June 30 (HealthDay News) -- Only half of hormone-sensitive stage I to III breast cancer patients prescribed adjuvant hormonal therapy adhere to that therapy for the full duration at the optimal schedule, and younger women in particular are at high risk of non-adherence, according to a study published online June 28 in the Journal of Clinical Oncology.

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Benzoyl Peroxide/Salicylic Acid Wins As Initial Acne Treatment

WEDNESDAY, June 30 (HealthDay News) -- Benzoyl peroxide (BPO) with salicylic acid (SA) works better than BPO with clindamycin (CL) for the initial treatment of acne, but after 10 to 12 weeks there is little difference in results between the two treatments, according to research published in the July issue of the Journal of the American Academy of Dermatology.

Abstract
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MMRV Vaccine Ups Fever and Seizure Risk

TUESDAY, June 29 (HealthDay News) -- Measles-mumps-rubella-varicella (MMRV) vaccination is associated with an increased risk of fever and seizure in young children, above that already associated with measles-containing vaccines, according to research published online June 29 in Pediatrics, confirming preliminary evidence from a previous study.

Abstract
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Lower CYP2C19 Function Plus Clopidogrel May Cause Harm

TUESDAY, June 29 (HealthDay News) -- Patients treated with clopidogrel who are carriers of the loss-of-function CYP2C19*2 allele may be at increased risk for cardiovascular events and death, according to research published in the July 6 issue of the Journal of the American College of Cardiology.

Abstract
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Statins May Slow Post-Surgery Cancer Recurrence

TUESDAY, June 29 (HealthDay News) -- In men who undergo radical prostatectomy for prostate cancer, those who take statins have a decreased risk of biochemical recurrence, according to research published online June 28 in Cancer.

Abstract
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New Guidelines Issued for Clopidogrel After FDA Warning

TUESDAY, June 29 (HealthDay News) -- The American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA) released a joint clinical alert on June 28 to guide physicians in the interpretation of the boxed warning recently placed on the antiplatelet drug clopidogrel (Plavix) by the U.S. Food and Drug Administration. The full text of the alert will be co-published online June 28 in the Journal of the American College of Cardiology and Circulation.

Full Text - JACC
Full Text - Circulation

Statins May Not Help High-Risk Patients With No CVD History

MONDAY, June 28 (HealthDay News) -- Statins do not appear to be associated with a reduced risk of death in people who are at increased risk for cardiovascular disease (CVD) but have no history of it, according to research published in the June 28 issue of the Archives of Internal Medicine.

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Doctors Agree Malpractice Fears Drive Overuse of Tests

MONDAY, June 28 (HealthDay News) -- A large majority of physicians agree that the practice of defensive medicine -- stemming from malpractice concerns -- is responsible for an overuse of medical tests and procedures, according to a research letter in the June 28 issue of the Archives of Internal Medicine.

Abstract
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Polycystic Kidney Growth Not Stopped by Sirolimus

MONDAY, June 28 (HealthDay News) -- Sirolimus does not stop polycystic kidney growth in individuals with autosomal dominant polycystic kidney disease (ADPKD) and early chronic kidney disease; everolimus, however, slows the increase in total kidney volume but does not slow the decline in progressive renal impairment in those with ADPKD, according to two studies published online June 26 in the New England Journal of Medicine to coincide with press conferences at the European Renal Association—European Dialysis and Transplant Association Congress, held from June 25 to 28 in Munich, Germany.

Abstract - Serra
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Abstract - Walz
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Two Studies Demonstrate Cardiac Risks of Rosiglitazone

MONDAY, June 28 (HealthDay News) -- New evidence suggests that rosiglitazone is associated with an increased risk of adverse cardiovascular outcomes, according to two studies published online June 28 in the Journal of the American Medical Association and the Archives of Internal Medicine. The studies were released online ahead of publication because of their relevance to an upcoming U.S. Food and Drug Administration meeting intended to review the safety of rosiglitazone.

Abstract - Graham
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Editorial
Abstract - Nissen/Wolski
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American Heart Association Comment

Digoxin May Increase Mortality Risk in Hemodialysis Patients

FRIDAY, June 25 (HealthDay News) -- Digoxin use by patients on hemodialysis is linked to increased mortality, particularly in patients who have low pre-dialysis potassium concentrations, according to research published online June 24 in the Journal of the American Society of Nephrology.

Abstract
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Statins May Lower Risk of Atrial Fibrillation in Heart Patients

FRIDAY, June 25 (HealthDay News) -- Statin therapy is associated with a reduced risk of developing atrial fibrillation (AF) among coronary artery disease patients, and lipid-lowering therapy (LLT) appears to reduce the risk of death and cardiovascular events among individuals who already have AF, according to research published in the June 15 issue of the American Journal of Cardiology.

Abstract - Kulik
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Abstract - Badheka
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Updated Recommendations for Endometriosis Released

FRIDAY, June 25 (HealthDay News) -- Women who suffer from endometriosis-related pain should be treated first with conservative, non-surgical approaches and then with more invasive options if pain does not resolve, and hysterectomy only as a last resort, according to a practice bulletin issued by the American College of Obstetricians and Gynecologists (ACOG) and published in the July issue of Obstetrics & Gynecology.

Abstract
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Dulera Inhaler Approved for Asthma

THURSDAY, June 24 (HealthDay News) -- Merck & Co.'s Dulera inhaler has been approved for people 12 and older whose asthma isn't controlled with other medication, the company said Thursday in a news release.

FDA

Menstrual Cycle, OCPs Affect High-Risk HPV Detection Rates

THURSDAY, June 24 (HealthDay News) -- The timing of human papillomavirus (HPV) testing within the menstrual cycle affects detection rates in women who are taking non-continuous oral contraceptives, as well as in women who are not on oral contraceptives, according to research published in the July issue of Obstetrics & Gynecology.

Abstract
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Gefitinib Extends Life in Lung Cancer Patients With Mutation

WEDNESDAY, June 23 (HealthDay News) -- Gefitinib, a tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR), is more effective than standard chemotherapy in extending life for patients with non-small-cell lung cancer (NSCLC) who have EGFR mutations, according to a study published in the June 24 issue of the New England Journal of Medicine.

Abstract
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Health Professionals Often Do Little to Help Smokers Quit

WEDNESDAY, June 23 (HealthDay News) -- Many health care professionals ask patients about smoking and advise them to quit but do not follow guidelines to help patients actually give up the habit, according to research published online May 27 in Nicotine & Tobacco Research.

Abstract
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Oral Bisphosphonate Use May Reduce Breast Cancer Risk

WEDNESDAY, June 23 (HealthDay News) -- The use of oral bisphosphonates by postmenopausal women appears to significantly reduce the risk of some breast cancers, according to a pair of studies published online June 21 in the Journal of Clinical Oncology.

Abstract - Chlebowski
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Abstract - Rennert
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Editorial

Folic Acid, B12 Do Not Reduce Vascular Events

TUESDAY, June 22 (HealthDay News) -- Supplementation with folic acid and vitamin B12 over an extended period does not have a beneficial effect on vascular outcomes in individuals who have had a myocardial infarction, but it also poses no excess cancer risk, according to a study in the June 23/30 issue of the Journal of the American Medical Association.

Abstract
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AML Drug Mylotarg Voluntarily Withdrawn From U.S. Market

TUESDAY, June 22 (HealthDay News) -- Gemtuzumab ozogamicin (Mylotarg) -- used in treating acute myeloid leukemia (AML) -- has been voluntarily withdrawn from the U.S. market following concerns over a recent clinical trial, according to a June 21 news release from the U.S. Food and Drug Administration.

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Spinal Surgical Site Infections Usually S. Aureus

TUESDAY, June 22 (HealthDay News) -- Both deep and superficial surgical site infections (SSIs) after spinal surgery are usually caused by Staphylococcus aureus; successful treatment of deep infections is possible with single stage debridement and intravenous antibiotics, and superficial infections can effectively be treated with local wound care and oral antibiotic therapy, according to research published in the June 1 issue of Spine.

Abstract
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Many Doctors Positive Toward Industry Gifts, Interactions

TUESDAY, June 22 (HealthDay News) -- Physicians from a wide array of specialties -- particularly surgeons, trainees, and those not familiar with their institutions' policies on industry interactions -- have positive attitudes toward the pharmaceutical and medical device industries' marketing-related activities, according to research published in the June issue of the Archives of Surgery.

Abstract
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Editorial (subscription or payment may be required)

Severe Colitis Reported in Child After Rituximab Treatment

MONDAY, June 21 (HealthDay News) -- Children treated with rituximab for nephrotic syndrome (NS) may be at risk for severe T-cell mediated ulcerative colitis, as demonstrated by a case study published online June 21 in Pediatrics.

Abstract
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PCBs Linked to Reduced Response to Vaccinations

MONDAY, June 21 (HealthDay News) -- Exposure to polychlorinated biphenyls (PCBs) early in life may reduce the effectiveness of childhood vaccinations and impair immune-system responses to infection, according to research published online June 20 in Environmental Health Perspectives.

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Rescue Antenatal Steroids Beneficial for Preterm Infants

MONDAY, June 21 (HealthDay News) -- If it has been at least 14 days since an initial dose of antenatal steroids, an additional course of rescue antenatal steroids administered to pregnant women at continued risk of premature delivery can improve their infants' postnatal respiratory function, according to research published in the June issue of the American Journal of Obstetrics & Gynecology.

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Interest by Physicians Can Play Role in Medication Adherence

FRIDAY, June 18 (HealthDay News) -- Patients whose doctors actively review their medication use and prescribing information are more likely to use inhaled corticosteroids (ICS) for asthma control as prescribed, according to research published online May 31 in the Journal of Allergy and Clinical Immunology.

Abstract
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ER Visits for Prescription Drug Misuse Climbing

FRIDAY, June 18 (HealthDay News) -- From 2004 to 2008, emergency department visits involving the non-medical use of prescription drugs increased substantially in the United States, according to research published in the June 18 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Gene Mutation Increases Clot Risk in Women on Tamoxifen

FRIDAY, June 18 (HealthDay News) -- Women taking adjuvant tamoxifen for early-stage breast cancer who develop a thromboembolism (TE) are nearly five times more likely to carry the factor V Leiden (FVL) mutation than women on the medication who don't have a TE, according to a study published online June 16 in the Journal of the National Cancer Institute.

Abstract
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Bone Health Supplements Don't Increase Coronary Calcium

FRIDAY, June 18 (HealthDay News) -- Postmenopausal women who take calcium plus vitamin D supplements for bone health do not increase their levels of coronary artery calcium (CAC) and increase their cardiovascular disease risk as a result, according to a study published online June 14 in Menopause.

Abstract
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Celecoxib Linked to Lower Rate of Gastrointestinal Events

THURSDAY, June 17 (HealthDay News) -- The cyclooxygenase (COX)-2 selective nonsteroidal anti-inflammatory drug (NSAID) celecoxib is associated with a lower risk of gastrointestinal adverse events than the NSAID diclofenac plus the proton pump inhibitor (PPI) omeprazole in patients with osteoarthritis or rheumatoid arthritis, according to a study published online June 17 in The Lancet.

Abstract
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Comment (subscription or payment may be required)

Duloxetine Beneficial in Treating Chronic Low Back Pain

THURSDAY, June 17 (HealthDay News) -- Duloxetine appears to significantly reduce pain and improve functioning in nondepressed individuals with non-neuropathic chronic low back pain (CLBP), according to a study published in the June 1 issue of Spine, though during the study, more subjects on duloxetine discontinued treatment because of adverse events than those on placebo.

Abstract
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Editorial (subscription or payment may be required)

Payment Cut for Chemo Linked to Higher Treatment Rate

THURSDAY, June 17 (HealthDay News) -- The Medicare Prescription Drug, Improvement, and Modernization Act, which steeply reduced payment rates for chemotherapy drugs given on an outpatient basis starting in January 2005, has resulted in an increased likelihood that Medicare recipients with lung cancer will receive chemotherapy, according to research published online June 17 in Health Affairs.

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Adding Ligation to Nadolol Not Beneficial in Variceal Bleeding

THURSDAY, June 17 (HealthDay News) -- Combining band ligation with the beta blocker nadolol may increase the odds of adverse events and may not be the most effective prophylaxis for first variceal bleeding from cirrhosis, according to research published in the July issue of Hepatology.

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Antiretroviral Regimens Reduce Mom-Baby HIV Transmission

WEDNESDAY, June 16 (HealthDay News) -- Various antiretroviral treatment options for lactating mothers and breast-feeding infants appear to reduce mother-to-child transmission of human immunodeficiency virus type-1 (HIV-1), according to two studies in the June 17 issue of the New England Journal of Medicine.

Abstract - Shapiro
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Abstract - Chasela
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In COPD, Oral, Intravenous Steroids Bring Same Outcomes

TUESDAY, June 15 (HealthDay News) -- Patients with chronic obstructive pulmonary disease (COPD) exacerbations treated with low-dose oral corticosteroids have outcomes similar to those treated with more costly and invasive high-dose intravenous corticosteroid therapy, according to research published in the June 16 issue of the Journal of the American Medical Association.

Abstract
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Editorial (subscription or payment may be required)

Tranexamic Acid Reduces Mortality in Trauma Patients

TUESDAY, June 15 (HealthDay News) -- Tranexamic acid may be an effective option for reducing bleeding and mortality among trauma patients, without increasing the risk of serious complications such as myocardial infarction, stroke, or pulmonary embolism, according to a study published online June 15 in The Lancet.

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Comment

Treatments Found Effective for Chronic Hepatitis E Infection

TUESDAY, June 15 (HealthDay News) -- Ribavirin and pegylated interferon-α may be effective in treating chronic hepatitis E virus (HEV) infection, according to two reports published online June 14 in the Annals of Internal Medicine.

Abstract - Mallet
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Abstract - Alric
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Higher BMI Linked to More Breast Cancer Recurrences

TUESDAY, June 15 (HealthDay News) -- Overweight and obese breast cancer patients are more likely to suffer recurrences than their thinner peers, who may benefit more from anastrozole, according to research published online June 14 in the Journal of Clinical Oncology.

Abstract
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Editorial

Costs Thwart Continued Care for Many Cancer Patients

MONDAY, June 14 (HealthDay News) -- Many cancer survivors delay or forgo medical care due to cost, and cancer survivors under 65 are more likely to put off or forgo care than those without a history of cancer, according to research published online June 14 in Cancer.

Abstract
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ARBs Linked to Modestly Higher Risk of Cancer Diagnosis

MONDAY, June 14 (HealthDay News) -- Angiotensin-receptor blockers (ARBs) appear to be associated with a modest increase in risk of a new cancer diagnosis, according to research published online June 14 in The Lancet Oncology.

Abstract
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Editorial (subscription or payment may be required)

Vaccination Ends Disparities in Pneumococcal Disease

MONDAY, June 14 (HealthDay News) -- The vaccination of young children with seven-valent pneumococcal conjugate vaccine (PCV7) in recent years has eliminated disparities in risk for vaccine-type invasive pneumococcal disease (IPD) associated with race and group child care attendance, according to a case-control study published online June 14 in Pediatrics.

Abstract
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Enhancing Red Blood Cells in Prostatectomy Judged Safe

MONDAY, June 14 (HealthDay News) -- The use of erythropoietin stimulating proteins (ESPs) in men with normal hemoglobin levels undergoing open radical retropubic prostatectomy is not associated with an increase in cardiovascular or thromboembolic complications, according to a study in the June issue of Urology.

Abstract
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Editorial (subscription or payment may be required)
Reply (subscription or payment may be required)

Bevacizumab Is Effective and Safe in Macular Degeneration

FRIDAY, June 11 (HealthDay News) -- Bevacizumab (Avastin) appears to be a safe and efficacious alternative to standard care for the treatment of wet age-related macular degeneration (AMD), according to a study published June 10 in BMJ.

Abstract
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Editorial (subscription or payment may be required)

Metformin in Diabetes Linked to Lower Breast Cancer Risk

FRIDAY, June 11 (HealthDay News) -- In women with type 2 diabetes, long-term metformin use is associated with a lower risk of breast cancer, according to research published in the June issue of Diabetes Care.

Abstract
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Rotavirus Prescribing Information, Labeling Changed

FRIDAY, June 11 (HealthDay News) -- New prescribing information and patient labeling for rotavirus vaccines has been approved by the U.S. Food and Drug Administration in response to reports of vaccine-acquired rotavirus infection in infants with severe combined immunodeficiency disorder (SCID), according to a report published in the June 11 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Aspirin Found Cost-Effective in Newly Diagnosed Diabetes

FRIDAY, June 11 (HealthDay News) -- In individuals age 40 and older who have been newly diagnosed with type 2 diabetes, regular aspirin use is a cost-effective strategy, according to a study in the June issue of Diabetes Care.

Abstract
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Hospira Expands Propofol and Lipsoyn Recall

FRIDAY, June 11 (HealthDay News) -- Hospira has alerted health care providers that it is expanding its March 31 recall of Propofol Injectable Emulsion 1 percent and Liposyn (Intravenous Fat Emulsion) products that include Liposyn II 10 percent, Liposyn II 20 percent, Liposyn III 10 percent, Liposyn III 20 percent, and Liposyn III 30 percent, as some of the containers may contain sub-visible inert stainless steel particles.

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Intensive Program Beats Usual Care for Diabetes Patients

THURSDAY, June 10 (HealthDay News) -- An intensive lifestyle intervention (ILI) program that restricts calories and increases exercise is able to improve cardiovascular disease (CVD) risk factors and reduce medication use and costs for individuals with type 2 diabetes better than usual care, according to a study in the June issue of Diabetes Care.

Abstract
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Year of Weekly Exenatide Beneficial in Type 2 Diabetes

THURSDAY, June 10 (HealthDay News) -- In patients with type 2 diabetes, a once-weekly formulation of exenatide is associated with sustained improvements in glycemic control and body weight over 52 weeks, and patients who switch from a twice-daily to a once-weekly regimen have further improvements in A1C and fasting plasma glucose, according to research published in the June issue of Diabetes Care.

Abstract
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H1N1, Seasonal Flu Have Similar Attack Rates

THURSDAY, June 10 (HealthDay News) -- The pandemic 2009 H1N1 influenza virus had transmissibility and clinical features similar to those of seasonal influenza A viruses, and the use of oseltamivir ring chemoprophylaxis -- along with quick identification and isolation of affected individuals -- effectively reduced the impact of 2009 H1N1 outbreaks in semiclosed settings, according to two studies published in the June 10 issue of the New England Journal of Medicine.

Abstract - Cowling
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Abstract - Lee
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Valproic Acid Use in Pregnancy Tied to Malformation Risk

THURSDAY, June 10 (HealthDay News) -- In pregnant women, first-trimester use of valproic acid is associated with significantly increased risks of five congenital malformations in addition to spina bifida, according to research published in the June 10 issue of the New England Journal of Medicine.

Abstract
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B Vitamins Show No Benefit in Slowing CAD Progression

WEDNESDAY, June 9 (HealthDay News) -- In patients with coronary artery disease (CAD) who have undergone percutaneous coronary intervention (PCI), subsequent therapy with folic acid/vitamin B12 lowers levels of total plasma homocysteine (tHcy) but does not have a beneficial effect on disease progression, according to a study in the June 1 issue of the American Journal of Cardiology.

Abstract
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NSAID Cardio Risk for Healthy People Varies by Drug

WEDNESDAY, June 9 (HealthDay News) -- Use of the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac and rofecoxib by healthy people is associated with an increased risk of cardiovascular death, but naproxen appears to have a safer cardiovascular risk profile, according to a study published online June 8 in Circulation: Cardiovascular Quality and Outcomes.

Abstract
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Alcohol Dependence Treatment Tied to Social Cost Savings

WEDNESDAY, June 9 (HealthDay News) -- Treatment for alcohol dependence may result in reduced median social costs associated with arrests, vehicle accidents and health care, according to a study in the May issue of Medical Care.

Abstract
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Pediatric Migraine Treatment Practices Vary Widely in ER

WEDNESDAY, June 9 (HealthDay News) -- In a sample of Canadian emergency departments, children seen for migraine headaches reported frequent occurrence of attacks, and were subject to significant treatment variations by emergency department physicians, according to research published online June 7 in Pediatrics.

Abstract
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Fatal Medication Errors Rise in July at Teaching Hospitals

TUESDAY, June 8 (HealthDay News) -- In July there is a significant increase in fatal medication errors at medical institutions, and this spike is at least partly due to the arrival of new medical residents, according to a study published online May 29 in the Journal of General Internal Medicine.

Abstract
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Gout Drug Effective and Safe in Chronic Stable Angina

TUESDAY, June 8 (HealthDay News) -- Allopurinol, a standard treatment for gout, appears to be effective and safe in prolonging exercise capacity in patients with chronic stable angina, according to a study published online June 8 in The Lancet.

Abstract
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Triple Combination Cream Reduces Melasma Severity

TUESDAY, June 8 (HealthDay News) -- Although using daily triple combination (TC) cream for 12 weeks is safe and effective in reducing melasma severity enough for patients to reduce administration to twice per week, most patients relapse, requiring resumption of daily therapy, according to a study in the June issue of the Journal of the American Academy of Dermatology.

Abstract
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Racial Differences Exist in Asthma Prevalence and Care

MONDAY, June 7 (HealthDay News) -- Racial and ethnic differences exist in the prevalence, treatment and outcomes of asthma among children with equal access to medical care, according to a study published online June 7 in the Archives of Pediatrics & Adolescent Medicine.

Abstract
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Anesthesia During Cancer Surgery May Impact Outcomes

MONDAY, June 7 (HealthDay News) -- The use of anesthesia during cancer surgery may impact long-term outcomes and risk of cancer recurrence, according to two articles published in the June issue of Anesthesia & Analgesia.

Abstract - Gottschalk
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Abstract - Forget
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Antibiotic Not Found to Reduce Breakthrough Bleeding

FRIDAY, June 4 (HealthDay News) -- Treatment with doxycycline does not appear to decrease unscheduled bleeding associated with the initiation of continuous oral contraceptive pills, according to research published in the June issue of Obstetrics & Gynecology.

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Low-Dose Estrogen Patch Linked to Lower Risk of Stroke

FRIDAY, June 4 (HealthDay News) -- Postmenopausal women who use low-dose estrogen transdermal patches have a lower risk of stroke compared to users of either high-dose estrogen patches or oral hormone replacement therapy (HRT), according to research published June 3 in BMJ.

Abstract
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Many on Bisphosphonates Lack Information About the Drugs

FRIDAY, June 4 (HealthDay News) -- Many individuals taking bisphosphonates are unfamiliar with potential adverse events associated with treatment and with the duration of treatment, according to a study in the May 1 issue of the Journal of the American Dental Association.

Abstract
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Antivirals in Compensated Cirrhosis Found Cost-Effective

FRIDAY, June 4 (HealthDay News) -- The antiviral treatment of patients with compensated cirrhosis may be the most cost-effective treatment option for patients with advanced liver disease caused by hepatitis C virus (HCV) infection, according to research published in the June issue of Liver Transplantation.

Abstract
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Many Ischemic Stroke Patients Arrive at ER Within Hour

FRIDAY, June 4 (HealthDay News) -- A substantial portion of ischemic stroke patients present to emergency departments within an hour of onset, and they are more likely to receive thrombolytic therapy than those who arrive later, but both factors present room for improvement, according to research published online June 3 in Stroke.

Abstract
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LDL Increase on Omega-3 Plus Simvastatin Only in Subgroup

FRIDAY, June 4 (HealthDay News) -- The increase in low-density lipoprotein (LDL) cholesterol that occurs with the addition of omega-3 treatment to simvastatin appears to happen mainly in those with low baseline LDL while on simvastatin alone, according to research published in the May 15 issue of the American Journal of Cardiology.

Abstract
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CDC: Many U.S. Teens Have Abused Prescription Drugs

THURSDAY, June 3 (HealthDay News) -- One in five students high school students in the United States has abused prescription drugs at some point, according to the 2009 National Youth Risk Behavior Survey, released June 3 by the U.S. Centers for Disease Control and Prevention.

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Early Heparin Beneficial in Pulmonary Embolism

THURSDAY, June 3 (HealthDay News) -- For patients with acute pulmonary embolism (PE), starting heparin early, while the patient is still in the emergency department, is associated with decreased mortality, according to research published in the June issue of Chest.

Abstract
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Combination Therapy Cuts Risk of Type 2 Diabetes Onset

THURSDAY, June 3 (HealthDay News) -- Low doses of rosiglitazone and metformin given in combination can substantially reduce the risk of progression to type 2 diabetes in people with impaired glucose tolerance who are at risk for the disease, according to a study published online June 3 in The Lancet.

Abstract
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Case Study Shows Poor Results of Back Pain Overtreatment

THURSDAY, June 3 (HealthDay News) -- For low back pain, overly aggressive surgical treatment and overtreatment with narcotics can result in severely adverse outcomes for the patient, including increased pain, loss of functionality and drug addiction, according to a case report in the May 20 issue of Spine.

Abstract
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Stroke Patients Benefit From Early Lipid-Lowering Therapy

THURSDAY, June 3 (HealthDay News) -- Early initiation of lipid-lowering therapy (LLT) during hospitalization for ischemic stroke or transient ischemic attack correlates with improved clinical outcomes, according to research published in the May 15 issue of the American Journal of Cardiology.

Abstract
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Sequential Treatment Linked to Improved Cancer Survival

WEDNESDAY, June 2 (HealthDay News) -- Doxorubicin and cyclophosphamide followed by docetaxel (sequential ACT) shows some survival benefit compared to doxorubicin-docetaxel or concurrent ACT in women with operable early breast cancer, according to research published in the June 3 issue of the New England Journal of Medicine.

Abstract
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Risk of GI Bleeding Varies by NSAID Type, Dosage

WEDNESDAY, June 2 (HealthDay News) -- The risk of gastrointestinal (GI) complications due to nonsteroidal anti-inflammatory drug (NSAID) use varies by the specific drug used and by dosage, and those with a slow-release formulation or long half-life are associated with a greater risk, according to research published in the June issue of Arthritis & Rheumatism.

Abstract
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Parkinson's Disease Drug Can Cause Corneal Damage

WEDNESDAY, June 2 (HealthDay News) -- Parkinson's disease patients taking the drug amantadine are at risk for damage to the corneal endothelium and resulting impaired vision, which can become more pronounced the longer the drug is used, according to research published in Ophthalmology.

Abstract
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Antidepressants May Increase Cataract Risk in Elderly

WEDNESDAY, June 2 (HealthDay News) -- Older people who take selective serotonin reuptake inhibitors (SSRIs) may be at increased risk for developing cataracts, according to research published in Ophthalmology.

Abstract
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Combination Strategy Best for Bleeding Prevention After PCI

TUESDAY, June 1 (HealthDay News) -- Patients undergoing percutaneous coronary intervention (PCI) who get bivalirudin in addition to a vascular closure device have the lowest bleeding risk, but patients with a high preprocedural bleeding risk are less likely to receive this treatment, according to research published in the June 2 issue of the Journal of the American Medical Association.

Abstract
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FDA: Claris IV Medications Recalled Due to Contamination

TUESDAY, June 1 (HealthDay News) -- The U.S. Food and Drug Administration has notified health care professionals not to use intravenous medications including metronidazole, ciprofloxacin and ondansetron manufactured by Claris Lifesciences, as the products may be contaminated.

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Antidepressants Associated With Miscarriage

TUESDAY, June 1 (HealthDay News) -- Use of antidepressants during pregnancy, particularly paroxetine, venlafaxine, or a combination of different antidepressant classes, may increase the risk of miscarriage by 68 percent, according to research published online May 31 in CMAJ, the journal of the Canadian Medical Association.

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