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Category: Endocrinology | Monthly Briefing

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August 2010 Briefing - Diabetes & Endocrinology

Last Updated: September 01, 2010.

 

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for August 2010. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Non-Physiologic Factors Sway Growth Hormone Decisions

TUESDAY, Aug. 31 (HealthDay News) -- Physicians' decisions to initiate growth hormone (GH) therapy in children with idiopathic short stature are mostly consistent with established guidelines, but their recommendations regarding GH continuation are more strongly influenced by contextual and attitudinal factors than by growth response to therapy, according to research published online Aug. 30 in Pediatrics.

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Type 1 Diabetes With ESRD Prognosis Has Improved

MONDAY, Aug. 30 (HealthDay News) -- The survival of patients with type 1 diabetes and end-stage renal disease (ESRD) receiving renal replacement therapy (RRT) has improved since 1980, even with an increase in the age of patients starting RRT, according to a study in the August issue of Diabetes Care.

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BPA Exposure May Be Related to Male Endocrine Changes

FRIDAY, Aug. 27 (HealthDay News) -- Bisphenol A (BPA) exposure may have an impact on male sex hormones, according to research published online Aug. 25 in Environmental Health Perspectives.

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Study Finds Vitamin D Links to Disease-Associated Genes

FRIDAY, Aug. 27 (HealthDay News) -- Vitamin D receptor (VDR) binding sites are significantly enriched at genes that have been linked to several autoimmune diseases and cancer, suggesting that vitamin D deficiency may be linked to disease pathogenesis, according to research published online Aug. 24 in Genome Research.

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Factor in Inflammation May Be Linked to Diabetes Risk

FRIDAY, Aug. 27 (HealthDay News) -- Plasma protein growth arrest-specific 6 (Gas6) -- a growth factor-like molecule -- is associated with inflammation, endothelial dysfunction, and altered glucose tolerance, and it may be a risk factor for type 2 diabetes, according to research published in the August issue of Diabetes Care.

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Type 2 Diabetes Susceptibility Alleles Tied to BMI in Children

THURSDAY, Aug. 26 (HealthDay News) -- In children who were born large for gestational age, certain type 2 diabetes susceptibility alleles are linked to low body mass index (BMI) at age 8, according to research published in the August issue of Diabetes.

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Diabetes, Insulin Resistance Tied to Alzheimer's Pathology

THURSDAY, Aug. 26 (HealthDay News) -- Individuals with type 2 diabetes and insulin resistance may be at an increased risk of developing brain plaques that are linked to Alzheimer's disease, according to a study published online Aug. 25 in Neurology.

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PTSD Among Service Members Linked to Diabetes Risk

THURSDAY, Aug. 26 (HealthDay News) -- In members of the U.S. military, posttraumatic stress disorder (PTSD) is associated with a higher risk of later self-reported diabetes, according to research published in the August issue of Diabetes Care.

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Diabetes Drugs Equal in Risk for Adverse Heart Events

WEDNESDAY, Aug. 25 (HealthDay News) -- The diabetes drugs rosiglitazone and pioglitazone (Avandia and Actos, respectively) appear to be evenly matched when it comes to the risk for acute myocardial infarction (AMI), acute heart failure (AHF), and mortality in patients taking the drugs, according to research published online Aug. 24 in Circulation: Cardiovascular Quality and Outcomes.

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Berberine Linked to Impaired Muscle Metabolism in Mice

WEDNESDAY, Aug. 25 (HealthDay News) -- The herbal compound berberine stimulates the expression of atrogin-1, leading to protein degradation, suppression of protein synthesis, and muscle atrophy in a mouse model of type 2 diabetes, according to research published in the August issue of Diabetes.

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Genetic Variants Associated With End-Stage Renal Disease

TUESDAY, Aug. 24 (HealthDay News) -- Genetic variants in protein kinase C-β 1 (PRKCB1) genes, the genes implicated in the development of complications in diabetes, are associated with the risk of end-stage renal disease (ESRD) in Chinese individuals with type 2 diabetes, according to a study in the Aug. 25 issue of the Journal of the American Medical Association.

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β Cells Still Functioning in Long-Time Diabetes Patients

MONDAY, Aug. 23 (HealthDay News) -- Some patients with type 1 diabetes mellitus (T1DM) still have functional pancreatic β cells after 50 years despite prolonged autoimmune and metabolic stress, suggesting that autoimmune stress reduction with stimulation of β cell regeneration could improve insulin production in individuals with diabetes, according to research published online Aug. 10 in Diabetes.

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High A1C Tied to Heart Failure in Those Without Diabetes

MONDAY, Aug. 23 (HealthDay News) -- Among middle-aged people without diabetes, elevated hemoglobin A1C is associated with risk of later heart failure, indicating that chronic hyperglycemia even before diabetes development may be a risk factor for heart failure, according to research published in the August issue of Diabetes.

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Leafy Green Vegetables May Reduce Type 2 Diabetes Risk

FRIDAY, Aug. 20 (HealthDay News) -- Higher daily consumption of green leafy vegetables can significantly reduce the risk of developing type 2 diabetes, according to a meta-analysis published Aug. 19 in BMJ.

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Fatty Acids Beneficial for Metabolic Syndrome Patients

WEDNESDAY, Aug. 18 (HealthDay News) -- Low-fat, high-complex carbohydrate diets are often recommended to lower risk for metabolic syndrome (MetS), but this regimen may raise blood lipids; the addition of long-chain (n-3) fatty acids may help alleviate this problem in MetS patients, according to research published online July 14 in the Journal of Nutrition.

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Vitamin D Insufficiency May Hurt Lymphoma Prognosis

TUESDAY, Aug. 17 (HealthDay News) -- In patients with two non-Hodgkin's lymphoma subtypes, vitamin D insufficiency is associated with inferior overall survival (OS) as well as inferior event-free survival (EFS), according to a study published online Aug. 16 in the Journal of Clinical Oncology.

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Bariatric Surgery for Diabetes Patients Cuts Medication, Costs

MONDAY, Aug. 16 (HealthDay News) -- In type 2 diabetes patients, bariatric surgery is associated with dramatic reductions in the use of diabetes medications and in annual health care costs in the years after surgery, according to research published in the August issue of the Archives of Surgery.

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Rimonabant Trial Stopped Early Due to Suicide Risk

FRIDAY, Aug. 13 (HealthDay News) -- A study evaluating the cardiovascular outcomes related to rimonabant, a weight loss drug, was discontinued due to concerns regarding the risk of suicide associated with the drug, according to a report in the Aug. 14 issue of The Lancet.

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Cholesterol Levels Vary Across the Menstrual Cycle

FRIDAY, Aug. 13 (HealthDay News) -- Serum lipid levels are associated with endogenous estrogen levels in menstruating women, and vary throughout the cycle, according to research published online June 9 in the Journal of Clinical Endocrinology and Metabolism.

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Maternal High-Fat Diet Tied to Offspring's Gene Expression

THURSDAY, Aug. 12 (HealthDay News) -- Maternal consumption of a high-fat diet during pregnancy and lactation may alter gene expression among offspring, according to an animal study published online Aug. 4 in Endocrinology.

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Gestational Glucose Tolerance Status May Affect Diabetes Risk

THURSDAY, Aug. 12 (HealthDay News) -- β-cell dysfunction progresses in women with a history of gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (GIGT) in the first year after giving birth, and may contribute to subsequent development of type 2 diabetes, according to research published in the August issue of Diabetes Care.

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Culturally Guided Diet Changes May Help Diabetes Prevention

THURSDAY, Aug. 12 (HealthDay News) -- Identification of dietary trends, such as levels of carbohydrate, protein, and fiber intake, in African-Americans without diabetes, with pre-diabetes, and with diabetes could potentially guide culturally-targeted diabetes prevention and treatment methods, according to research published in the Spring issue of Ethnicity & Disease.

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Patients, Doctors Often Have Communication Discrepancies

WEDNESDAY, Aug. 11 (HealthDay News) -- Hospitalized patients and physicians may have differing beliefs regarding patients' knowledge and aspects of their care, suggesting a need for improved patient-physician communication, according to research published in the Aug. 9/23 issue of the Archives of Internal Medicine.

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Consumer Drug Information Shows Areas of Concern

WEDNESDAY, Aug. 11 (HealthDay News) -- Consumer medication information (CMI) accompanying prescription drugs dispensed at retail pharmacies is often subject to concerns about format, comprehensibility, and excessive length, according to research published in the Aug. 9/23 issue of the Archives of Internal Medicine.

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Retinopathy Common Among Adults With Diabetes in U.S.

TUESDAY, Aug. 10 (HealthDay News) -- Middle-aged and older Americans with diabetes have a high prevalence of diabetic retinopathy -- including vision-threatening retinopathy -- a finding that is especially notable in non-Hispanic blacks, according to research published in the Aug. 11 issue of the Journal of the American Medical Association.

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Even With Normal BMI, Larger Waist Tied to Higher Mortality

MONDAY, Aug. 9 (HealthDay News) -- Increased waist circumference is associated with a higher mortality risk in normal weight, overweight, and obese individuals, according to research published in the Aug. 9/23 issue of the Archives of Internal Medicine.

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Coping Style, Depression Linked to Foot Ulcer Outcomes

FRIDAY, Aug. 6 (HealthDay News) -- Depression and a confrontational coping style may be associated with lack of healing of diabetic foot ulcers, according to research published in the August issue of Diabetologia.

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Podiatric Care Reduces Amputation Risk in Diabetes

FRIDAY, Aug. 6 (HealthDay News) -- Foot amputation or hospitalization resulting from foot ulcers in diabetes patients can be prevented or delayed with timely care from a podiatrist, and increased podiatry use by diabetes patients may result in substantial health care cost savings, according to research presented at the annual scientific meeting of the American Podiatric Medical Association, held from July 15 to 18 in Seattle.

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Rosiglitazone May Help Maintain Cognition in Diabetes Patients

FRIDAY, Aug. 6 (HealthDay News) -- Adding rosiglitazone to the treatment for type 2 diabetes may help protect against cognitive decline in older patients with mild cognitive impairment, according to a study in the August issue of Diabetes Care.

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Omentectomy Not Linked to Better Metabolic Function

FRIDAY, Aug. 6 (HealthDay News) -- In obese patients, surgical removal of the omentum, either alone or along with Roux-en-Y gastric bypass, doesn't improve metabolic function, according to research published in the August issue of Gastroenterology.

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Diabetes May Alter Obese Adolescents' Brain Structure

THURSDAY, Aug. 5 (HealthDay News) -- Obese adolescents with type 2 diabetes have decreased cognitive functioning and subtle brain abnormalities compared to obese adolescents without diabetes, according to research published online July 29 in Diabetologia.

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Grand Multiparity Associated With Diabetes

THURSDAY, Aug. 5 (HealthDay News) -- Grand multiparity (giving birth to five or more children)is associated with diabetes in elderly women, but the relationship may be mediated by sociodemographic factors, according to research published in the August issue of Diabetes Care.

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Diabetes Education for PCPs Improves Disease Management

THURSDAY, Aug. 5 (HealthDay News) -- Diabetes patients from clinics where primary care physicians (PCPs) participate in a program of computer-based diabetes case studies improve glucose control better than patients from clinics where PCPs do not undergo the learning intervention, according to a study in the August issue of Diabetes Care.

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Diabetes Linked to Reduced Pulmonary Function

THURSDAY, Aug. 5 (HealthDay News) -- Diabetes, without the presence of overt pulmonary disease, is linked to a small but significant degree of pulmonary function impairment in a restrictive pattern, according to research published in the August issue of Chest.

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Quality-Adjusted Life Years Lost Due to Obesity Swells

WEDNESDAY, Aug. 4 (HealthDay News) -- The quality-adjusted life years (QALYs) lost among U.S. adults as the result of obesity more than doubled from 1993 to 2008, a period during which the nation's obesity prevalence increased by 89.9 percent, according to a report published online Aug. 3 in the American Journal of Preventive Medicine.

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Diabetes Drug Spurs Weight Loss, Better Cardiac Profile

WEDNESDAY, Aug. 4 (HealthDay News) -- In type 2 diabetes patients, treatment with a glucagon-like peptide (GLP-1) receptor agonist is associated with weight loss and an improved cardiovascular risk profile, according to research published in the August issue of Diabetes Care.

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U.S. Obesity Prevalence Among Adults Increased in 2009

WEDNESDAY, Aug. 4 (HealthDay News) -- In 2009, no U.S. state met the Healthy People 2010 adult obesity prevalence target of 15 percent, and the number of states with an obesity prevalence ≥30 increased from zero in 2000 to nine in 2009, according to the U.S. Centers for Disease Control and Prevention's Vital Signs report published Aug. 3 in the Morbidity and Mortality Weekly Report.

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Environmental Traits, Mom's Obesity Tied to Type 1 Diabetes

TUESDAY, Aug. 3 (HealthDay News) -- Consistent with the hygiene and overload hypotheses, environmental factors associated with less antigenic exposure in early life and maternal obesity may be associated with risk for type 1 diabetes, according to a study published in the August issue of the Archives of Pediatrics & Adolescent Medicine.

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Industry-Funded Clinical Trials Yield More Positive Outcomes

TUESDAY, Aug. 3 (HealthDay News) -- Drug clinical trials supported by industry are more likely to produce favorable results than trials supported by government or nonprofit/nonfederal organizations, and they are less likely to be published within two years of the study being completed, according to research published in the Aug. 3 issue of the Annals of Internal Medicine.

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Increasing Weight, Waist Move Impaired Glucose to Diabetes

MONDAY, Aug. 2 (HealthDay News) -- Increases in both weight and waist circumference in those who already have impaired fasting glucose (IFG) are significantly related to incidence of type 2 diabetes, with an enlarging waist being particularly risky for those with a lower body mass index (BMI), according to research published in the August issue of Diabetes Care.

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Oral Antidiabetic Agents Usually Drop A1C 1.5 Percent or Less

MONDAY, Aug. 2 (HealthDay News) -- Oral antidiabetic (OAD) agents generally result in a maximum 1.5 percent drop in A1C levels, with sulfonylureas and thiazolidinediones having a slightly more beneficial effect than other classes of oral agents, according to research published in the August issue of Diabetes Care.

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Higher Vitamin K Intake May Reduce Risk of Diabetes

MONDAY, Aug. 2 (HealthDay News) -- Higher intake of the biologically active forms of vitamin K, phylloquinone and menaquinones, may reduce the risk of type 2 diabetes, according to research published in the August issue of Diabetes Care.

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